Evidence map›Paper›PMID 32601200›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Inhibition of

Kenji Rowel Q Lim, Rika Maruyama, Yusuke Echigoya, Quynh Nguyen, Aiping Zhang, Hunain Khawaja, Sreetama Sen Chandra, Takako Jones, Peter Jones, Yi-Wen Chen and 1 more

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Molecular therapy. Nucleic acids · 2026
    Article
  3. Antisense RNA therapies for muscular dystrophies.Journal of neuromuscular diseases · 2026
    Review
  4. Muscular Dystrophies.Advances in experimental medicine and biology · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Molecular and Phenotypic Changes in FLExDUX4 Mice.Journal of personalized medicine · 2023
    Article
  12. Article
  13. Influence ofInternational journal of molecular sciences · 2023
    Review
  14. Article
  15. Current Strategies of Muscular Dystrophy Therapeutics: An Overview.Methods in molecular biology (Clifton, N.J.) · 2023
    Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Kenji Rowel Q LimDepartment of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G2H7, Canada.ORCID 0000-0002-5484-4183
Rika MaruyamaDepartment of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G2H7, Canada.ORCID 0000-0002-5656-6930
Yusuke EchigoyaDepartment of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G2H7, Canada.ORCID 0000-0003-1573-4819
Quynh NguyenDepartment of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G2H7, Canada.ORCID 0000-0003-1330-9026
Aiping ZhangCenter for Genetic Medicine Research, Children's National Health System, Washington, DC 20010.
Hunain KhawajaCenter for Genetic Medicine Research, Children's National Health System, Washington, DC 20010.
Sreetama Sen ChandraCenter for Genetic Medicine Research, Children's National Health System, Washington, DC 20010.
Takako JonesDepartment of Pharmacology, University of Nevada Reno School of Medicine, Reno, NV 89557-0318.
Peter JonesDepartment of Pharmacology, University of Nevada Reno School of Medicine, Reno, NV 89557-0318.
Yi-Wen ChenCenter for Genetic Medicine Research, Children's National Health System, Washington, DC 20010; YChen@childrensnational.org toshifumi@ualberta.ca.
Toshifumi YokotaDepartment of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G2H7, Canada; YChen@childrensnational.org toshifumi@ualberta.ca.ORCID 0000-0001-6672-6742
Children's National · USUniversity of Alberta · CAUniversity of Nevada, Reno · USNihon University · JP

Funding

Mechanisms of DUX4 mediated FSHD pathologyR01AR062587 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI JONES, PETER L · 2013 to 2024
$5.3M
CIHRNIAMS NIH HHS R01 AR062587
6 · The paper itself

Abstract

Facioscapulohumeral muscular dystrophy (FSHD), characterized by progressive muscle weakness and deterioration, is genetically linked to aberrant expression of

Indexed as

Genetic TherapyAnimalsDisease Models, AnimalGene Knockdown TechniquesHomeodomain ProteinsHumansMiceMuscular Dystrophy, FacioscapulohumeralMyoblastsOligonucleotides, AntisenseDux4 protein, mouseHomeodomain ProteinsOligonucleotides, Antisenseantisense therapyDUX4facioscapulohumeral muscular dystrophyFLExDUX4 mouse modelLNA gapmers

Identifiers

PMID32601200
PMCPMC7368245
OpenAlexW3037823855

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.