ArticleProceedings of the National Academy of Sciences of the United States of America2020
LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors.
Open access · hybridAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- CAFs shape the immunosuppressive microenvironment of pancreatic cancer through the Lin28b-STING Axis.Nature communications · 2026Article
- Core transcriptional regulatory circuitry identified from patient-derived tumor cells provides a specific vulnerability for rhabdomyosarcoma.Cell death & disease · 2026Article
- Developmental reprogramming underlies chemotherapy resistance in favorable-histology Wilms tumor.Cell reports · 2026Article
- Ribosomal protein control of hematopoietic stem cell transformation through regulation of metabolism.Cell reports · 2025Article
- Disruption of the KLHL37-N-Myc complex restores N-Myc degradation and arrests neuroblastoma growth in mouse models.The Journal of clinical investigation · 2025Article
- Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma.Cancer research · 2025Article
- Molecular regulation and therapeutic targeting ofFrontiers in cell and developmental biology · 2025Review
- Association ofBiomedicines · 2024Article
- The Role of Zinc in Developed Countries in Pediatric Patients: A 360-Degree View.Biomolecules · 2024Review
- Liver cancer initiation requires translational activation by an oncofetal regulon involving LIN28 proteins.The Journal of clinical investigation · 2024Article
- Eflornithine for treatment of high-risk neuroblastoma.Trends in pharmacological sciences · 2024Article
- Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma.Cell reports. Medicine · 2024Article
- The Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epithelium.Nature communications · 2023Article
- Review
- Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state.The Journal of clinical investigation · 2023Article
- ATF1 promotes the malignancy of lung adenocarcinoma cells by transcriptionally regulating ZNF143 expression.Acta biochimica et biophysica Sinica · 2023Article
- The role of ZNF143 overexpression in rat liver cell proliferation.BMC genomics · 2022Article
- LIN28B inhibition sensitizes cells to p53-restoring PPI therapy through unleashed translational suppression.Oncogenesis · 2022Article
- miR-99b-5p, miR-380-3p, and miR-485-3p are novel chemosensitizing miRNAs in high-risk neuroblastoma.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- DOCK9 antisense RNA2 interacts with LIN28B to stabilize Wnt5a and boosts proliferation and migration of oxidized low densitylipoprotein-induced vascular smooth muscle cells.Bioengineered · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 1 country.
Ting TaoDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.ORCID 0000-0003-1260-2351
Hui ShiDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.ORCID 0000-0002-6947-9668
Luca MarianiDepartment of Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-3502-7364
Brian J AbrahamDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.ORCID 0000-0001-8085-3027
Adam D DurbinDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.ORCID 0000-0002-5472-9847
Mark W ZimmermanDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
John T PowersDivision of Pediatric Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
Pavlos MissiosDivision of Pediatric Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
Kenneth N RossDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
Antonio R Perez-AtaydeDepartment of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-8036-6288
Martha L BulykDepartment of Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115; mlbulyk@genetics.med.harvard.edu young@wi.mit.edu george.daley@childrens.harvard.edu thomas_look@dfci.harvard.edu.
Richard A YoungWhitehead Institute for Biomedical Research, Cambridge, MA 02142; mlbulyk@genetics.med.harvard.edu young@wi.mit.edu george.daley@childrens.harvard.edu thomas_look@dfci.harvard.edu.
George Q DaleyStem Cell Program, Division of Hematology/Oncology, Manton Center for Orphan Disease Research, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115; mlbulyk@genetics.med.harvard.edu young@wi.mit.edu george.daley@childrens.harvard.edu thomas_look@dfci.harvard.edu.ORCID 0000-0002-6346-5919
A Thomas LookDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215; mlbulyk@genetics.med.harvard.edu young@wi.mit.edu george.daley@childrens.harvard.edu thomas_look@dfci.harvard.edu.
Harvard University · USBoston Children's Hospital · USBroad Institute · USBrigham and Women's Hospital · USSt. Jude Children's Research Hospital · USWhitehead Institute for Biomedical Research · US
Funding
Mechanisms and Vulnerabilities of Aberrant Transcriptional Enhancers in CancerR35CA210064 · NCI · DANA-FARBER CANCER INST · PI LOOK, A. THOMAS · 2016 to 2022
$7.3MRole of LMO1 in Neuroblastoma Initiation and MaintenanceR01CA180692 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI LOOK, A. THOMAS, MARIS, JOHN M · 2015 to 2019
$3.0MSurveying transcription factor pioneer interactions with nucleosomal DNAR21HG009268 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI BULYK, MARTHA L · 2016 to 2019
$1.4MNCI NIH HHS R01 CA180692NCI NIH HHS R35 CA210064NHGRI NIH HHS R21 HG009268
Abstract
LIN28B is highly expressed in neuroblastoma and promotes tumorigenesis, at least, in part, through inhibition of
Indexed as
AnimalsAnimals, Genetically ModifiedCell MovementGene Expression Regulation, NeoplasticHumansMicroRNAsNeuroblastomaN-Myc Proto-Oncogene ProteinProtein BindingRNA-Binding ProteinsTrans-ActivatorsZebrafishLIN28B protein, humanMicroRNAsmirnlet7 microRNA, humanMYCN protein, humanN-Myc Proto-Oncogene ProteinRNA-Binding ProteinsTrans-ActivatorsZNF143 protein, humanLIN28Bneuroblastomatranscriptional regulationzebrafish modelZNF143
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.