Evidence map›Paper›PMID 32601106›Full record

ArticleMolecular and cellular biology2020

MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.

Ji-Eun Lee, Young-Wook Cho, Chu-Xia Deng, Kai Ge

Open access · bronzeAbstract read
In one paragraph

Article in Molecular and cellular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
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  3. Review
  4. Article
  5. Article
  6. Bee (Food science & nutrition · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Wds-Mediated H3K4me3 Modification Regulates Lipid Synthesis and Transport inInternational journal of molecular sciences · 2023
    Article
  11. Inhibition Effect of Adipogenesis and Lipogenesis via Activation ofInternational journal of molecular sciences · 2023
    Article
  12. Article
  13. Review
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Ji-Eun Lee *Adipocyte Biology and Gene Regulation Section, Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), Bethesda, Maryland, USA.ORCID 0000-0002-3768-7016
Young-Wook Cho *Adipocyte Biology and Gene Regulation Section, Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), Bethesda, Maryland, USA.ORCID 0000-0002-8247-5995
Chu-Xia DengGenetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), Bethesda, Maryland, USA.
Kai GeAdipocyte Biology and Gene Regulation Section, Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), Bethesda, Maryland, USA kai.ge@nih.gov.ORCID 0000-0002-7442-5138
National Institutes of Health · US

Funding

Regulation of PPARgamma Expression and Adipogenesis by PTIP-Associated FactorsZIADK075003 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GE, KAI · 2009 to 2025
$17.6M
Epigenomic Regulation of PPARgamma and AdipogenesisZIADK075017 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GE, KAI · 2009 to 2025
$12.4M
6 · The paper itself

Abstract

Transcription factors C/EBPβ and C/EBPδ are induced within hours after initiation of adipogenesis in culture. They directly promote the expression of master adipogenic transcription factors peroxisome proliferator-activated receptor γ (PPARγ) and C/EBPα and are required for adipogenesis

Indexed as

3T3-L1 CellsAdipocytesAdipogenesisAdipose Tissue, BrownAnimalsCCAAT-Enhancer-Binding Protein-betaCCAAT-Enhancer-Binding Protein-deltaCell Cycle ProteinsCell DifferentiationDNA-Binding ProteinsHistone-Lysine N-MethyltransferaseHistone MethyltransferasesMiceMice, KnockoutPPAR gammaProtein BindingCCAAT-Enhancer-Binding Protein-betaCCAAT-Enhancer-Binding Protein-deltaCell Cycle ProteinsDNA-Binding ProteinsHistone-Lysine N-MethyltransferaseHistone MethyltransferasesKmt2c protein, mouseMLL4 protein, mousePPAR gammaadipogenesisC/EBPβC/EBPδPAGR1

Identifiers

PMID32601106
PMCPMC7431048
OpenAlexW3037385521

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.