Observational studyArchives of disease in childhood2020
Cross-sectional study of population-specific streptococcal antibody titres in Uganda.
Observational study in Archives of disease in childhood, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Early-life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high-burden setting.Nature medicine · 2025Article
- Streptococcal Serology Reference Intervals in an Australian Pediatric Cohort.Journal of the Pediatric Infectious Diseases Society · 2025Article
- Determination of the upper limit of normal for serum anti-streptolysin-O titre in primary school children in Southern Nigeria; A model for other low resource settings.International journal of cardiology. Cardiovascular risk and prevention · 2024Article
- Revising the value of Antistreptolysin O titre in childhood and its interpretation in the diagnostic approach of rheumatic diseases.European journal of pediatrics · 2024Article
- Correlates of immunity to Group A Streptococcus: a pathway to vaccine development.NPJ vaccines · 2023Review
- Standardization of Epidemiological Surveillance of Acute Rheumatic FeverOpen forum infectious diseases · 2022Article
- Recent Advances in the Rheumatic Fever and Rheumatic Heart Disease Continuum.Pathogens (Basel, Switzerland) · 2022Review
- Study of streptococcal antibody (anti-streptolysin O) among healthy children in Bangladesh.SAGE open medicine · 2022Article
- Normal values of antistreptolysin O for adults ages 30 to 70 in Syria: A cross sectional study.Annals of medicine and surgery (2012) · 2021Article
- Incidence of acute rheumatic fever in northern and western Uganda: a prospective, population-based study.The Lancet. Global health · 2021Article
- The "Cairo Accord"- Towards the Eradication of RHD: An Update.Frontiers in cardiovascular medicine · 2021Review
- Active Case Finding for Rheumatic Fever in an Endemic Country.Journal of the American Heart Association · 2020Article
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Authors and funding
21 authors.
Funding
Abstract
objectiveDespite substantial variation of streptococcal antibody titres among global populations, there is no data on normal values in sub-Saharan Africa. The objective of this study was to establish normal values for antistreptolysin O (ASO) and antideoxyribonuclease B (ADB) antibodies in Uganda.
designThis was an observational cross-sectional study.
settingThis study was conducted at Mulago National Referral Hospital, which is located in the capital city, Kampala, and includes the Uganda Heart Institute. PATIENTS: Participants (aged 0-50 years) were recruited. Of 428 participants, 22 were excluded from analysis, and 183 (44.4%) of the remaining were children aged 5-15 years.
main outcome measuresASO was measured in-country by nephelometric technique. ADB samples were sent to Australia (PathWest) for analysis by enzyme inhibition assay: 80% upper limit values were established.
resultsThe median ASO titre in this age group was 220 IU/mL, with the 80th percentile value of 389 IU/mL. The median ADB titre in this age group was 375 IU/mL, with the 80th percentile value of 568 IU/mL.
conclusionsThe estimated Ugandan paediatric population standardised 80% upper-limit-of-normal ASO and ADB titres is higher than many global populations. Appropriateness of using population-specific antibody cutoffs is yet to be determined and has important implications for the sensitivity and specificity of rheumatic fever diagnosis.
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