Evidence map›Paper›PMID 32601068›Full record

ArticleJournal of bacteriology2020

S1 Domain RNA-Binding Protein CvfD Is a New Posttranscriptional Regulator That Mediates Cold Sensitivity, Phosphate Transport, and Virulence in Streptococcus pneumoniae D39.

Dhriti Sinha, Jiaqi J Zheng, Ho-Ching Tiffany Tsui, John D Richardson, Nicholas R De Lay, Malcolm E Winkler

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bacteriology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Calcium RescuesMicroorganisms · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Single-Nucleotide RNA Maps for the Two Major Nosocomial PathogensFrontiers in cellular and infection microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Dhriti Sinha *Department of Biology, Indiana University Bloomington, Bloomington, Indiana, USA.
Jiaqi J Zheng *Department of Biology, Indiana University Bloomington, Bloomington, Indiana, USA.
Ho-Ching Tiffany TsuiDepartment of Biology, Indiana University Bloomington, Bloomington, Indiana, USA.
John D RichardsonDepartment of Biology, Indiana University Bloomington, Bloomington, Indiana, USA.
Nicholas R De LayDepartment of Microbiology and Molecular Genetics, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA nicholas.r.delay@uth.tmc.edu winklerm@indiana.edu.
Malcolm E WinklerDepartment of Biology, Indiana University Bloomington, Bloomington, Indiana, USA nicholas.r.delay@uth.tmc.edu winklerm@indiana.edu.ORCID 0000-0002-1482-2588
Indiana University Bloomington · USThe University of Texas Health Science Center at Houston · US

Funding

New Regulatory Interactions and Circuits that Mediate the Dynamics, Homeostasis, and Stress Responses of Peptidoglycan Synthesis in the Superbug Streptococcus pneumoniaeR35GM131767 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI MALCOLM E. WINKLER · 2019 to 2026
$4.8M
Spaciotemporal Regulation of Specific Penicillin Binding Protein (PBP) Function Determined by New Activity-Based ApproachesR01GM128439 · NIGMS · UNIVERSITY OF MINNESOTA · PI CARLSON, ERIN ELIZABETH, WINKLER, MALCOLM E. · 2018 to 2019
$936k
New Regulatory Circuits that Mediate Peptidoglycan Homeostasis and Cell Wall Stress Responses in the Superbug Streptococcus pneumoniaeR01GM127715 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI WINKLER, MALCOLM E. · 2018 to 2019
$630k
NIGMS NIH HHS R01 GM127715NIGMS NIH HHS R01 GM128439NIGMS NIH HHS R35 GM131767
6 · The paper itself

Abstract

Posttranscriptional gene regulation often involves RNA-binding proteins that modulate mRNA translation and/or stability either directly through protein-RNA interactions or indirectly by facilitating the annealing of small regulatory RNAs (sRNAs). The human pathogen

Indexed as

Cold-Shock ResponseAnimalsBacterial ProteinsDisease Models, AnimalGene Expression Regulation, BacterialMaleMiceMice, Inbred ICRPhosphatesPneumococcal InfectionsRibosomal ProteinsRNA-Binding ProteinsStreptococcus pneumoniaeVirulenceVirulence FactorsBacterial ProteinsPhosphatesRibosomal Proteinsribosomal protein S1RNA-Binding ProteinsVirulence Factorscold sensitivityphosphate uptakepleiotropic regulationpneumococcusposttranscriptional regulationRNA-binding proteinvirulence attenuation

Identifiers

PMID32601068
PMCPMC7925082
OpenAlexW3040279712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.