ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2020
Nausea and vomiting in pregnancy is not just 'morning sickness': data from a prospective cohort study in the UK.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Treatment of Nausea and Vomiting With Zingiber officinale in Pregnancy: An Umbrella Review of Systematic Reviews With Meta-Synthesis.Phytotherapy research : PTR · 2026Pooled it
- Acupuncture for nausea and vomiting during pregnancy: an overview of systematic reviews.Frontiers in endocrinology · 2026Pooled it
- Nausea and Vomiting in Pregnancy: Prevalence, Clinical Characteristics, and Management Findings from a Prospective Italian Multicenter Cohort Study.Life (Basel, Switzerland) · 2026Article
- Bioavailability of CaribanDrugs in R&D · 2023Article
- Patterns of antiemetic medication use during pregnancy: A multi-country retrospective cohort study.PloS one · 2022Article
- The onset of nausea and vomiting of pregnancy: a prospective cohort study.BMC pregnancy and childbirth · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNausea and vomiting in pregnancy is usually called 'morning sickness'. This is felt by sufferers to trivialise the condition. Symptoms have been described as occurring both before and after noon, but daily symptom patterns have not been clearly described and statistically modelled to enable the term 'morning sickness' to be accurately analysed.
aimTo describe the daily variation in nausea and vomiting symptoms during early pregnancy in a group of sufferers. DESIGN AND
settingA prospective cohort study of females recruited from 15 May 2014 to 17 February 2017 by Swiss Precision Diagnostics (SPD) Development Company Limited, which was researching hormone levels in early pregnancy and extended its study to include the description of pregnancy symptoms.
methodDaily symptom diaries of nausea and vomiting were kept by females who were trying to conceive. They also provided daily urine samples, which when analysed enabled the date of ovulation to be determined. Data from 256 females who conceived during the first month of the study are included in this article. Daily symptom patterns and changes in daily patterns by week of pregnancy were modelled. Functional data analysis was used to produce estimated symptom probability functions.
resultsThere was a peak probability of nausea in the morning, a lower but sustained probability of nausea throughout the day, and a slight peak in the evening. Vomiting had a defined peak incidence in the morning.
conclusionReferring to nausea and vomiting in pregnancy as simply 'morning sickness' is inaccurate, simplistic, and therefore unhelpful.
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