Evidence map›Paper›PMID 32600465›Full record

ArticleStem cell research & therapy2020

Cutaneous wound healing: canine allogeneic ASC therapy.

Nathaly Enciso, Luis Avedillo, María Luisa Fermín, Cristina Fragío, Concepción Tejero

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 35 citations in OpenAlex.

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  12. An Outstanding Role of Adipose Tissue in Canine Stem Cell Therapy.Animals : an open access journal from MDPI · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Nathaly Enciso"Experimental Hematology" UCM-Research Group, Veterinary Faculty, Complutense University of Madrid, Avda Puerta de Hierro s/n, 28040, Madrid, Spain.
Luis Avedillo"Experimental Hematology" UCM-Research Group, Veterinary Faculty, Complutense University of Madrid, Avda Puerta de Hierro s/n, 28040, Madrid, Spain.
María Luisa Fermín"Experimental Hematology" UCM-Research Group, Veterinary Faculty, Complutense University of Madrid, Avda Puerta de Hierro s/n, 28040, Madrid, Spain.
Cristina Fragío"Experimental Hematology" UCM-Research Group, Veterinary Faculty, Complutense University of Madrid, Avda Puerta de Hierro s/n, 28040, Madrid, Spain.
Concepción Tejero"Experimental Hematology" UCM-Research Group, Veterinary Faculty, Complutense University of Madrid, Avda Puerta de Hierro s/n, 28040, Madrid, Spain. contejor@ucm.es.ORCID 0000-0003-4142-7935
Universidad Complutense de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWound healing is a complex biological process comprised of a series of sequential events aiming to repair injured tissue. Adult mesenchymal stem cells (MSCs) have been used in cellular therapy in preclinical animal studies; a promising source of MSCs is adipose tissue (AT). In this paper, we evaluated the clinical value and safety of the application of cultured allogenic MSCs from AT for acute and chronic skin wound healing in a canine model.

methodsTwenty-four dogs of different breeds between 1 and 10 years of age with acute and chronic wounds were studied. Morphology of the wounded skin was monitored for changes over time via serial photographs and histopathological studies.

resultsThe percentage of the wounds that exhibited contraction and re-epithelialization were significantly different between wounds treated with adipose mesenchymal stem cells (ASCs) and control wounds; this effect was observed in both acute and chronic conditions. At 90 days, re-epithelization of acute and chronic wounds reached more than 97%. Histopathological study revealed a reduction in inflammatory infiltrate and the presence of multiple hair follicles on day 7 after treatment with ASCs, promoting epidermal and dermal regeneration. To guarantee the safety of our treatment, we determined the serum levels of cytokine markers in our patients. ASC treatment upregulated granulocyte-macrophage colony stimulating factor (GM-CSF) at the gene level, which may contribute to the recruitment of cells that participate in skin repair to the site of injury.

conclusionsThe development of an allogenic ASC therapy to improve wound healing in a canine model could have a clinical impact in human treatment.

Indexed as

Hematopoietic Stem Cell TransplantationMesenchymal Stem CellsAdipose TissueAdultAnimalsDogsHumansSkinWound HealingAdipose mesenchymal stem cellsASC therapyCanine cutaneous woundsRegenerative medicine

Identifiers

PMID32600465
PMCPMC7325024
OpenAlexW3040275060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.