Evidence map›Paper›PMID 32600448›Full record

ArticleBMC public health2020

Model of genetic and environmental factors associated with type 2 diabetes mellitus in a Chinese Han population.

Zheng Li, Cheng-Yin Ye, Tian-Yu Zhao, Lei Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Frontiers in endocrinology · 2021
    Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Zheng LiMedical School, Hangzhou Normal University, 2318 Yuhangtang Rd, Hangzhou, 310000, Zhejiang, China.
Cheng-Yin YeMedical School, Hangzhou Normal University, 2318 Yuhangtang Rd, Hangzhou, 310000, Zhejiang, China.
Tian-Yu ZhaoMedical School, Hangzhou Normal University, 2318 Yuhangtang Rd, Hangzhou, 310000, Zhejiang, China.
Lei YangMedical School, Hangzhou Normal University, 2318 Yuhangtang Rd, Hangzhou, 310000, Zhejiang, China. yanglei62@hznu.edu.cn.ORCID http://orcid.org/0000-0001-7618-9936
Hangzhou Normal University · CNShihezi University · CN

Funding

2011R50021 2011R50021
6 · The paper itself

Abstract

backgroundType 2 diabetes mellitus (T2DM) is a metabolic disorder which accounts for high morbidity and mortality due to complications like renal failure, amputations, cardiovascular disease, and cerebrovascular events.

methodsWe collected medical reports, lifestyle details, and blood samples of individuals and used the polymerase chain reaction-ligase detection reaction method to genotype the SNPs, and a visit was conducted in August 2016 to obtain the incidence of Type 2 diabetes in the 2113 eligible people. To explore which genes and environmental factors are associated with type 2 diabetes mellitus in a Chinese Han population, we used elastic net to build a model, which is to explain which variables are strongly associated with T2DM, rather than predict the occurrence of T2DM.

resultThe genotype of the additive of rs964184, together with the history of hypertension, regular intake of meat and waist circumference, increased the risk of T2DM (adjusted OR = 2.38, p = 0.042; adjusted OR = 3.31, p < 0.001; adjusted OR = 1.05, p < 0.001). The TT genotype of the additive and recessive models of rs12654264, the CC genotype of the additive and dominant models of rs2065412, the TT genotype of the additive and dominant models of rs4149336, together with the degree of education, regular exercise, reduced the risk of T2DM (adjusted OR = 0.46, p = 0.017; adjusted OR = 0.53, p = 0.021; adjusted OR = 0.59, p = 0.021; adjusted OR = 0.57, p = 0.01; adjusted OR = 0.59, p = 0.021; adjusted OR = 0.57, p = 0.01; adjusted OR = 0.50, p = 0.007; adjusted OR = 0.80, p = 0.032) .

conclusionEventually we identified a set of SNPs and environmental factors: rs5805 in the SLC12A3, rs12654264 in the HMGCR, rs2065412 and rs414936 in the ABCA1, rs96418 in the ZPR1 gene, waistline, degree of education, exercise frequency, hypertension, and the intake of meat. Although there was no interaction between these variables, people with two risk factors had a higher risk of T2DM than those only having one factor. These results provide the theoretical basis for gene and other risk factors screening to prevent T2DM.

Indexed as

AgedAsian PeopleATP Binding Cassette Transporter 1CarbolinesChinaDiabetes Mellitus, Type 2FemaleGenetic Predisposition to DiseaseGenotypeHumansHydroxymethylglutaryl CoA ReductasesLife StyleMaleMembrane Transport ProteinsMiddle AgedPolymorphism, Single NucleotideABCA1 protein, humanATP Binding Cassette Transporter 1CarbolinesdiazolineHMGCR protein, humanHydroxymethylglutaryl CoA ReductasesMembrane Transport ProteinsZPR1 protein, humanElastic netEnvironmental factorsSingle-nucleotide polymorphismType 2 diabetes mellitus

Identifiers

PMID32600448
PMCPMC7325035
OpenAlexW3039732878

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.