ArticleBMC microbiology2020
Role of tryptophan-metabolizing microbiota in mice diarrhea caused by Folium sennae extracts.
Article in BMC microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- Time-Resolved Epithelial Responses to ETEC-K88 Reveal Tryptophan-Linked Protection in IPEC-J2 Cells and Strain-Specific Intestinal Injury in Mice.Animals : an open access journal from MDPI · 2026Article
- The gut microbial metabolite 3-indolepropionic acid as a functional neuroprotective agent against intracerebral hemorrhage: integrating epidemiological screening with in vivo validation.Metabolic brain disease · 2026Article
- Article
- Canine epidermal growth factor-expressing Lactococcus lactis promotes intestinal injury repair and alleviates diarrhea in canine.BMC veterinary research · 2026Article
- Association of intestinal mucosal barrier function with intestinal microbiota in Spleen-Kidney Yang Deficiency IBS-D mice.Frontiers in microbiology · 2025Article
- Article
- One of the Short-Chain Fatty Acids (SCFAs), Sodium Propionate, Can Reduce the Dosage of Sishen Pill in Regulating the Intestinal Microbiota in Diarrhea with Kidney-Yang Deficiency Syndrome.Journal of inflammation research · 2025Article
- Article
- Amino acids in piglet diarrhea: Effects, mechanisms and insights.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Review
- Intestinal mucosal microbiota mediate amino acid metabolism involved in the gastrointestinal adaptability to cold and humid environmental stress in mice.Microbial cell factories · 2024Article
- Targeted remodeling of the human gut microbiome using Juemingzi (Frontiers in cellular and infection microbiology · 2024Article
- Sishen Pill inhibits intestinal inflammation in diarrhea mice via regulating kidney-intestinal bacteria-metabolic pathway.Frontiers in pharmacology · 2024Article
- Intestinal tryptophan metabolism in disease prevention and swine production.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Review
- Article
- The dysfunction in intestinal microorganisms and enzyme activity as significant contributors to diarrhea with kidney-yang deficiency syndrome.Frontiers in microbiology · 2023Article
- Correlation Between Kidney Function and Intestinal Biological Characteristics of Adenine and Folium SennaeInduced Diarrhea Model in Mice.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023Article
- Article
- Antidiarrheal Effect of Fermented Millet Bran on Diarrhea Induced by Senna Leaf in Mice.Foods (Basel, Switzerland) · 2022Article
- Importance ofFrontiers in nutrition · 2022Article
- Diarrhea with deficiency kidney-yang syndrome caused by adenine combined withFrontiers in microbiology · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAlthough reports have provided evidence that diarrhea caused by Folium sennae can result in intestinal microbiota diversity disorder, the intestinal bacterial characteristic and specific mechanism are still unknown. The objective of our study was to investigate the mechanism of diarrhea caused by Folium sennae, which was associated with intestinal bacterial characteristic reshaping and metabolic abnormality.
resultsFor the intervention of Folium sennae extracts, Chao1 index and Shannon index were statistical decreased. The Beta diversity clusters of mice interfered by Folium sennae extracts were distinctly separated from control group. Combining PPI network analysis, cytochrome P450 enzymes metabolism was the main signaling pathway of diarrhea caused by Folium sennae. Moreover, 10 bacterial flora communities had statistical significant difference with Folium sennae intervention: the abundance of Paraprevotella, Streptococcus, Epulopiscium, Sutterella and Mycoplasma increased significantly; and the abundance of Adlercreutzia, Lactobacillus, Dehalobacterium, Dorea and Oscillospira reduced significantly. Seven of the 10 intestinal microbiota communities were related to the synthesis of tryptophan derivatives, which affected the transformation of aminotryptophan into L-tryptophan, leading to abnormal tryptophan metabolism in the host.
conclusionsFolium sennae targeted cytochrome P450 3A4 to alter intestinal bacterial characteristic and intervene the tryptophan metabolism of intestinal microbiota, such as Streptococcus, Sutterella and Dorea, which could be the intestinal microecological mechanism of diarrhea caused by Folium sennae extracts.
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