Evidence map›Paper›PMID 32600312›Full record

ArticleBMC veterinary research2020

Gut microbiota profiles of commercial laying hens infected with tumorigenic viruses.

Xianhua Wan, Laipeng Xu, Xiangli Sun, Hui Li, Fengbin Yan, Ruili Han, Hong Li, Zhuanjian Li, Yadong Tian, Xiaojun Liu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Xianhua WanCollege of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450000, China.
Laipeng XuCollege of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450000, China.
Xiangli SunCollege of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450000, China.
Hui LiCollege of Environmental and Resource Sciences, Henan Agricultural University, Zhengzhou, 450000, China.
Fengbin YanCollege of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450000, China.
Ruili HanCollege of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450000, China.
Hong LiCollege of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450000, China.
Zhuanjian LiCollege of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450000, China.
Yadong TianCollege of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450000, China.
Xiaojun LiuCollege of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450000, China.
Xiangtao KangCollege of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450000, China.
Zhenya WangKey Laboratory of "Runliang" Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, 450001, China. zhenyawang@zzu.edu.cn.
Yanbin WangCollege of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450000, China. ybwang2008@henau.edu.cn.
Henan Agricultural University · CNZhengzhou University · CN

Funding

Education Department of Henan Province 18A350012
6 · The paper itself

Abstract

backgroundStudies have shown that some viral infections cause structural changes in the intestinal microflora, but little is known about the effects of tumorigenic viral infection on the intestinal microflora of chickens.

resultsA 29-week commercial layer flock positive for avian leukosis virus-J (ALV-J), Marek's disease virus (MDV) and avian reticuloendotheliosis virus (REV) was selected, and fresh fecal samples were collected and examined for the composition of the gut microflora by Illumina sequencing of the V3-V4 region of the 16S rRNA gene. The operational taxonomic units (OTUs) of the fecal microbiota differentiated the chickens infected with only ALV-J and those coinfected with ALV-J and MDV or REV from infection-negative chickens. The enrichment and diversity of cloacal microflora in chickens infected with ALV-J alone were slightly different from those in the infection-negative chickens. However, the diversity of cloacal microflora was significantly increased in chickens coinfected with both ALV-J and MDV or REV.

conclusionsThe intestinal microbiota was more strongly disturbed in chickens after coinfection with ALV-J and MDV or REV than after infection with ALV-J alone, and there may be underlying mechanisms by which the capacity for the stabilization of the intestinal flora was impaired due to viral infection and tumorigenesis.

Indexed as

Gastrointestinal MicrobiomeAnimalsAvian LeukosisAvian Leukosis VirusBacteriaChickensCoinfectionFecesFemaleHerpesvirus 2, GallidMarek DiseasePoultry DiseasesReticuloendotheliosis virusRetroviridae InfectionsRNA, Ribosomal, 16STumor Virus InfectionsRNA, Ribosomal, 16S16S rRNAALV-JFecal microfloraMDVREV

Identifiers

PMID32600312
PMCPMC7324990
OpenAlexW3037668970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.