ReviewBMC pediatrics2020
Severe constipation as the first clinical manifestation in multiple endocrine neoplasia type 2B: a case report and literature review.
Review in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Postoperative outcomes of pediatric patients with perioperative COVID-19 infection: a systematic review and meta-analysis of observational studies.Journal of anesthesia · 2024Pooled it
- COVID- 19 in patients affected by red blood cell disorders, results from the European registry ERN-EuroBloodNet.Orphanet journal of rare diseases · 2025Article
- Shut-up Toys for Second Language Learners: Impact of Digital Media on Early Adolescents' Private Speech Production in Individual and Collaborative Tasks.Journal of psycholinguistic research · 2024Article
- Coronavirus disease 2019-related Kawasaki syndrome: a case report.Journal of medical case reports · 2022Article
- Lower skeletal muscle mass on CT body composition analysis is associated with adverse clinical course and outcome in children with COVID-19.La Radiologia medica · 2022Article
- Demographic, clinical, and paraclinical characteristics of COVID-19 pediatric cases in southeast Iran.Antimicrobial resistance and infection control · 2021Article
- Outcome of SARS-CoV-2 Infection in 121 Patients with Inborn Errors of Immunity: A Cross-Sectional Study.Journal of clinical immunology · 2021Article
- Transmission frequency of COVID-19 through pre-symptomatic and asymptomatic patients in AJK: a report of 201 cases.Virology journal · 2021Article
- A narrative review of multiple endocrine neoplasia syndromes: genetics, clinical features, imaging findings, and diagnosis.Annals of translational medicine · 2021Review
- Suspension of Hip Surveillance for Children with Cerebral Palsy During the COVID-19 Outbreak: The Benefit of Hip Surveillance Does Not Outweigh the Risk of Infection.Indian journal of orthopaedics · 2021Review
- Possible role of vitamin D in Covid-19 infection in pediatric population.Journal of endocrinological investigation · 2021Review
- [Suspected sepsis in a 10-week-old infant and SARS-CoV-2 detection in cerebrospinal fluid and pharynx].Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde · 2021Article
- Kawasaki Disease Features and Myocarditis in a Patient with COVID-19.Pediatric cardiology · 2020Article
- Best practice for infection prevention in pediatric respiratory clinics during the COVID-19 epidemic.World journal of pediatrics : WJP · 2020Review
- Management of patients with SARS-CoV-2 infections and of patients with chronic lung diseases during the COVID-19 pandemic (as of 9 May 2020) : Statement of the Austrian Society of Pneumology (ASP).Wiener klinische Wochenschrift · 2020Article
- The trinity of COVID-19: immunity, inflammation and intervention.Nature reviews. Immunology · 2020Review
- [Statement of the Austrian Society of Pneumology (ASP)].Wiener klinisches Magazin : Beilage zur Wiener klinischen Wochenschrift · 2020Review
- [Coronavirus: from common cold to severe pulmonary failure].Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde · 2020Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
backgroundThe occurrence of multiple endocrine neoplasia type 2B (MEN2B) in Asians is very rare. In particular, patients with intractable constipation as the main clinical manifestation are even rarer. Atypical clinical manifestations are likely to lead to a diagnostic delay. In this report, we described a case of a delayed diagnosis of MEN2B, and the first clinical manifestation was intractable constipation. CASE PRESENTATION: A female teenager had suffered from intractable constipation since infancy. Because the colonoscopy and biopsy results from local hospitals did not confirm the presence of congenital megacolon, the girl had been followed up at a local clinic for a long time. The diagnosis was not confirmed until thyroid masses were found in the Pediatric Department of Shanghai Ruijin Hospital when she was 12 years old. According to our detailed evaluation, she suffered from Hirschsprung disease (HD), growth retardation, medullary thyroid carcinoma (MTC) and mucosal neuroma due to a mutation in the RET gene. Thus, the diagnosis of MEN2B was confirmed. Afterward, the girl underwent several surgeries and was still being followed up before the article was published.
conclusionMEN2B has atypical clinical symptoms in the early stage. Refractory constipation may be the only clinical manifestation that lasts for several years. Therefore, we recommend that early screening and gene sequencing should be performed for patients with severe constipation due to HD to determine the cause of the disease and to improve the survival outcome.
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