Observational studyBMC pediatrics2020
Association between admission hypothermia and outcomes in very low birth weight infants in China: a multicentre prospective study.
Observational study in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Factors influencing hypothermia in very low/extremely low birth weight infants: a meta-analysis.PeerJ · 2023Pooled it
- The cellular ecosystem of skeletal muscle regeneration: molecular mechanisms, pathological disorders, and potential therapeutic strategies.Stem cell research & therapy · 2026Review
- Advanced thermoregulation by access port covers in neonatal transport incubators: computational fluid dynamics analysis.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Feasibility and early outcomes of intact cord resuscitation without special equipment in extremely preterm infants born at 23-25 weeks of gestation: A case series.European journal of pediatrics · 2025Article
- Prevalence of Neonatal Hypothermia and Associated Risk Factors at a Referral Hospital in Northern Province, Rwanda.Rwanda journal of medicine and health sciences · 2025Article
- Delayed admission temperature normalisation in preterm infants <32 weeks: impact on mortality and neonatal morbidities.BMJ paediatrics open · 2025Article
- The Chinese adverse prognosis of very preterm infants (CARE-Preterm) cohort: study design and baseline characteristics for a prospective multicenter cohort study.BMC pediatrics · 2025Article
- Delivery-room and NICU admission temperatures in preterm infants <32 weeks at a tertiary centre in Saudi Arabia: associations with mortality and morbidity.Frontiers in pediatrics · 2025Article
- Association between Neonatal Outcomes and Admission Hypothermia among Very Preterm Infants in Chinese Neonatal Intensive Care Units: A Multicenter Cohort Study.American journal of perinatology · 2024Article
- Comparative evaluation of axillary and rectal temperatures across different gestational ages in newborns admitted to the neonatal intensive care unit: a cross-sectional study.BMC pediatrics · 2024Article
- Impact of early caffeine administration on respiratory outcomes in very preterm infants initially receiving invasive mechanical ventilation.BMJ open respiratory research · 2024Observational
- Hypothermia in preterm infants admitted to low-resource neonatal units in northern Nigeria: an observational study of occurrence and risk factors.BMC pediatrics · 2024Observational
- Article
- [Pulmonary hemorrhage in very low birth weight infants: risk factors and clinical outcome].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- A standardized implementation of multicenter quality improvement program of very low birth weight newborns could significantly reduce admission hypothermia and improve outcomes.BMC pediatrics · 2022Article
- Implementation of a temperature bundle improves admission hypothermia in very-low-birth-weight infants in China: a multicentre study.BMJ open quality · 2022Article
- Relationship between Admission Temperature and Risk of Cerebral Palsy in Infants Admitted to Special Care Unit in a Low Resource Setting: A Retrospective Single-Center Study.Children (Basel, Switzerland) · 2022Article
- Maintaining Normothermia in Preterm Babies during Stabilisation with an Intact Umbilical Cord.Children (Basel, Switzerland) · 2022Article
- Admission Hypothermia and Factors Associated with Mortality among Admitted Hypothermic Preterm Neonates in Neonatal Intensive Care Units of Public Hospitals of Addis Ababa, Ethiopia.International journal of pediatrics · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 20 institutions in 1 country.
Funding
Abstract
backgroundThe objective of this prospective, multicentre, observational cohort study was to evaluate the association between admission hypothermia and neonatal outcomes in very low-birth weight (VLBW) infants in multiple neonatal intensive care units (NICUs) in China.
methodsSince January 1, 2018, a neonatal homogeneous cooperative research platform-Shandong Neonatal Network (SNN) has been established. The platform collects clinical data in a prospective manner on preterm infants with birth weights (BWs) < 1500 g and gestational ages (GAs) < 34 weeks born in 28 NICUs in Shandong Province. These infants were divided into normothermia, mild or moderate/severe hypothermia groups according to the World Health Organization (WHO) classifications of hypothermia. Associations between outcomes and hypothermia were tested in a bivariate analysis, followed by a logistic regression analysis.
resultsA total of 1247 VLBW infants were included in this analysis, of which 1100 infants (88.2%) were included in the hypothermia group, 554 infants (44.4%) in the mild hypothermia group and 546 infants (43.8%) in the moderate/severe hypothermia group. Small for gestational age (SGA), caesarean section, a low Apgar score at 5 min and intubation in the delivery room (DR) were related to admission hypothermia (AH). Mortality was the lowest when their admission temperature was 36.5 ~ 37.5 °C, and after adjustment for maternal and infant characteristics, mortality was significantly associated with AH. Compared with infants with normothermia (36.5 ~ 37.5 °C), the adjusted ORs of all deaths increased to 4.148 (95% CI 1.505-11.437) and 1.806 (95% CI 0.651-5.009) for infants with moderate/severe hypothermia and mild hypothermia, respectively. AH was also associated with a high likelihood of respiratory distress syndrome (RDS), intraventricular haemorrhage (IVH), and late-onset neonatal sepsis (LOS).
conclusionsAH is still very high in VLBW infants in NICUs in China. SGA, caesarean section, a low Apgar score at 5 min and intubation in the DR were associated with increased odds of hypothermia. Moderate/severe hypothermia was associated with mortality and poor outcomes, such as RDS, IVH, LOS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.