Evidence map›Paper›PMID 32600156›Full record

ReviewAnnual review of virology2020

Regulators of Viral Frameshifting: More Than RNA Influences Translation Events.

Wesley D Penn, Haley R Harrington, Jonathan P Schlebach, Suchetana Mukhopadhyay

Open access · greenAbstract readReview
In one paragraph

Review in Annual review of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  9. Review
  10. Ribosomal frameshifting selectively modulates the assembly, function, and pharmacological rescue of a misfolded CFTR variant.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
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  15. Review
  16. Evolution of coronavirus frameshifting elements: Competing stem networks explain conservation and variability.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Wesley D PennDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, USA.
Haley R HarringtonDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, USA.
Jonathan P SchlebachDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, USA.
Suchetana MukhopadhyayDepartment of Biology, Indiana University, Bloomington, Indiana 47405, USA; email: sumukhop@indiana.edu.
Indiana University Bloomington · US

Funding

Topological Heterogeneity as an Evolved Source of Structural Diversity in Viral PolyproteinsR21AI142383 · NIAID · TRUSTEES OF INDIANA UNIVERSITY · PI SCHLEBACH, JONATHAN PATRICK · 2019 to 2020
$413k
NIAID NIH HHS R21 AI142383
6 · The paper itself

Abstract

Programmed ribosomal frameshifting (PRF) is a conserved translational recoding mechanism found in all branches of life and viruses. In bacteria, archaea, and eukaryotes PRF is used to downregulate protein production by inducing a premature termination of translation, which triggers messenger RNA (mRNA) decay. In viruses, PRF is used to drive the production of a new protein while downregulating the production of another protein, thus maintaining a stoichiometry optimal for productive infection. Traditionally, PRF motifs have been defined by the characteristics of two

Indexed as

Evolution, MolecularFrameshifting, RibosomalGene Expression Regulation, ViralProtein BiosynthesisHumansNucleic Acid ConformationRibosomesRNA, MessengerRNA, ViralRNA, MessengerRNA, Viralcis-acting elementsmRNA regulatorsPRFprogrammed ribosomal frameshiftingprotein regulatorstrans-acting elements

Identifiers

PMID32600156
PMCPMC8310556
OpenAlexW3040072159

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.