ArticleThe American journal of psychiatry2021
Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology.
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Article in The American journal of psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.
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49citing papers in PubMed, 4 pooled it
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Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Identification of a diagnosis-selective neurobiological substrate for bipolar disorder, major depressive disorder, and schizophrenia: a meta-analysis of 57,717 subjects.Psychological medicine · 2026Pooled it
- The hierarchical taxonomy of psychopathology and the search for neurobiological substrates of mental illness: A systematic review and roadmap for future research.Journal of psychopathology and clinical science · 2024Pooled it
- A transdiagnostic network for psychiatric illness derived from atrophy and lesions.Nature human behaviour · 2023Pooled it
- Application of a diathesis-stress model to the interplay of cortical structural development and emerging depression in youth.Clinical psychology review · 2020Pooled it
- Personality change in a trial of psilocybin therapy v. escitalopram treatment for depression.Psychological medicine · 2024Trial
- Cerebellar Functional Alterations During Executive Functioning Are Associated With General Psychopathology in a Cross-Diagnostic Sample.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Transcranial direct current stimulation and lesions hierarchically reorganize brain network dynamics with biological annotations.Fundamental research · 2026Article
- Associations of general and specific psychopathology factors by age 35 with dementia after age 50: a Swedish population-based sibling comparison study.Molecular psychiatry · 2026Article
- Alterations in resting-state functional connectivity relate to psychopathology trajectories during emerging adolescence.JCPP advances · 2026Article
- Neurodevelopment as a shared genetic etiology linking sleep-related phenotypes and psychiatric disorders: a genome-wide pleiotropic analysis.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Transdiagnostic prevention in youth mental health, Part I: rationale, shared risk factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Article
- Prospective Relations between Cortical Thickness and Change in Internalizing Symptoms are Moderated by Chronic Stress Exposure in Adolescents with Depression and Anxiety.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Brain connectomes in youth at risk for serious mental illness: a longitudinal perspective.Brain imaging and behavior · 2025Article
- Transdiagnostic Clinical Staging in Youth Mental Health: A primer for clinical practice.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Review
- Article
- MULTIMODAL NEURAL CORRELATES OF CHILDHOOD PSYCHOPATHOLOGY.bioRxiv : the preprint server for biology · 2024Article
- Comparing the stability and reproducibility of brain-behavior relationships found using canonical correlation analysis and partial least squares within the ABCD sample.Network neuroscience (Cambridge, Mass.) · 2024Article
- Neural variability in three major psychiatric disorders.Molecular psychiatry · 2023Article
- Neurobiological Clusters Are Associated With Trajectories of Overall Psychopathology in Youth.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
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Authors and funding
13 authors.
Adrienne L RomerLaboratory of NeuroGenetics (Romer, Elliott, Knodt, Sison, Hariri), Department of Psychology and Neuroscience (Romer, Knodt, Houts, Moffitt, Caspi, Hariri), Department of Psychiatry and Behavioral Sciences (Moffitt, Caspi), and Center for Genomic and Computational Biology (Moffitt, Caspi), Duke University, Durham, N.C.; Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand (Ireland, Ramrakha, Poulton); Christchurch Radiology Group, Christchurch, New Zealand (Keenan); Department of Medicine, University of Otago, Christchurch (Melzer); New Zealand Brain Research Institute, Christchurch (Melzer); Social, Genetic, and Developmental Psychiatry Research Center, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Moffitt, Caspi); and McLean Hospital/Harvard Medical School, Belmont, Mass. (Romer).
Maxwell L ElliottLaboratory of NeuroGenetics (Romer, Elliott, Knodt, Sison, Hariri), Department of Psychology and Neuroscience (Romer, Knodt, Houts, Moffitt, Caspi, Hariri), Department of Psychiatry and Behavioral Sciences (Moffitt, Caspi), and Center for Genomic and Computational Biology (Moffitt, Caspi), Duke University, Durham, N.C.; Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand (Ireland, Ramrakha, Poulton); Christchurch Radiology Group, Christchurch, New Zealand (Keenan); Department of Medicine, University of Otago, Christchurch (Melzer); New Zealand Brain Research Institute, Christchurch (Melzer); Social, Genetic, and Developmental Psychiatry Research Center, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Moffitt, Caspi); and McLean Hospital/Harvard Medical School, Belmont, Mass. (Romer).
Annchen R KnodtLaboratory of NeuroGenetics (Romer, Elliott, Knodt, Sison, Hariri), Department of Psychology and Neuroscience (Romer, Knodt, Houts, Moffitt, Caspi, Hariri), Department of Psychiatry and Behavioral Sciences (Moffitt, Caspi), and Center for Genomic and Computational Biology (Moffitt, Caspi), Duke University, Durham, N.C.; Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand (Ireland, Ramrakha, Poulton); Christchurch Radiology Group, Christchurch, New Zealand (Keenan); Department of Medicine, University of Otago, Christchurch (Melzer); New Zealand Brain Research Institute, Christchurch (Melzer); Social, Genetic, and Developmental Psychiatry Research Center, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Moffitt, Caspi); and McLean Hospital/Harvard Medical School, Belmont, Mass. (Romer).
Maria L SisonLaboratory of NeuroGenetics (Romer, Elliott, Knodt, Sison, Hariri), Department of Psychology and Neuroscience (Romer, Knodt, Houts, Moffitt, Caspi, Hariri), Department of Psychiatry and Behavioral Sciences (Moffitt, Caspi), and Center for Genomic and Computational Biology (Moffitt, Caspi), Duke University, Durham, N.C.; Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand (Ireland, Ramrakha, Poulton); Christchurch Radiology Group, Christchurch, New Zealand (Keenan); Department of Medicine, University of Otago, Christchurch (Melzer); New Zealand Brain Research Institute, Christchurch (Melzer); Social, Genetic, and Developmental Psychiatry Research Center, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Moffitt, Caspi); and McLean Hospital/Harvard Medical School, Belmont, Mass. (Romer).
David IrelandLaboratory of NeuroGenetics (Romer, Elliott, Knodt, Sison, Hariri), Department of Psychology and Neuroscience (Romer, Knodt, Houts, Moffitt, Caspi, Hariri), Department of Psychiatry and Behavioral Sciences (Moffitt, Caspi), and Center for Genomic and Computational Biology (Moffitt, Caspi), Duke University, Durham, N.C.; Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand (Ireland, Ramrakha, Poulton); Christchurch Radiology Group, Christchurch, New Zealand (Keenan); Department of Medicine, University of Otago, Christchurch (Melzer); New Zealand Brain Research Institute, Christchurch (Melzer); Social, Genetic, and Developmental Psychiatry Research Center, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Moffitt, Caspi); and McLean Hospital/Harvard Medical School, Belmont, Mass. (Romer).
Renate HoutsLaboratory of NeuroGenetics (Romer, Elliott, Knodt, Sison, Hariri), Department of Psychology and Neuroscience (Romer, Knodt, Houts, Moffitt, Caspi, Hariri), Department of Psychiatry and Behavioral Sciences (Moffitt, Caspi), and Center for Genomic and Computational Biology (Moffitt, Caspi), Duke University, Durham, N.C.; Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand (Ireland, Ramrakha, Poulton); Christchurch Radiology Group, Christchurch, New Zealand (Keenan); Department of Medicine, University of Otago, Christchurch (Melzer); New Zealand Brain Research Institute, Christchurch (Melzer); Social, Genetic, and Developmental Psychiatry Research Center, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Moffitt, Caspi); and McLean Hospital/Harvard Medical School, Belmont, Mass. (Romer).
Sandhya RamrakhaLaboratory of NeuroGenetics (Romer, Elliott, Knodt, Sison, Hariri), Department of Psychology and Neuroscience (Romer, Knodt, Houts, Moffitt, Caspi, Hariri), Department of Psychiatry and Behavioral Sciences (Moffitt, Caspi), and Center for Genomic and Computational Biology (Moffitt, Caspi), Duke University, Durham, N.C.; Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand (Ireland, Ramrakha, Poulton); Christchurch Radiology Group, Christchurch, New Zealand (Keenan); Department of Medicine, University of Otago, Christchurch (Melzer); New Zealand Brain Research Institute, Christchurch (Melzer); Social, Genetic, and Developmental Psychiatry Research Center, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Moffitt, Caspi); and McLean Hospital/Harvard Medical School, Belmont, Mass. (Romer).
Richie PoultonLaboratory of NeuroGenetics (Romer, Elliott, Knodt, Sison, Hariri), Department of Psychology and Neuroscience (Romer, Knodt, Houts, Moffitt, Caspi, Hariri), Department of Psychiatry and Behavioral Sciences (Moffitt, Caspi), and Center for Genomic and Computational Biology (Moffitt, Caspi), Duke University, Durham, N.C.; Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand (Ireland, Ramrakha, Poulton); Christchurch Radiology Group, Christchurch, New Zealand (Keenan); Department of Medicine, University of Otago, Christchurch (Melzer); New Zealand Brain Research Institute, Christchurch (Melzer); Social, Genetic, and Developmental Psychiatry Research Center, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Moffitt, Caspi); and McLean Hospital/Harvard Medical School, Belmont, Mass. (Romer).
Ross KeenanLaboratory of NeuroGenetics (Romer, Elliott, Knodt, Sison, Hariri), Department of Psychology and Neuroscience (Romer, Knodt, Houts, Moffitt, Caspi, Hariri), Department of Psychiatry and Behavioral Sciences (Moffitt, Caspi), and Center for Genomic and Computational Biology (Moffitt, Caspi), Duke University, Durham, N.C.; Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand (Ireland, Ramrakha, Poulton); Christchurch Radiology Group, Christchurch, New Zealand (Keenan); Department of Medicine, University of Otago, Christchurch (Melzer); New Zealand Brain Research Institute, Christchurch (Melzer); Social, Genetic, and Developmental Psychiatry Research Center, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Moffitt, Caspi); and McLean Hospital/Harvard Medical School, Belmont, Mass. (Romer).
Tracy R MelzerLaboratory of NeuroGenetics (Romer, Elliott, Knodt, Sison, Hariri), Department of Psychology and Neuroscience (Romer, Knodt, Houts, Moffitt, Caspi, Hariri), Department of Psychiatry and Behavioral Sciences (Moffitt, Caspi), and Center for Genomic and Computational Biology (Moffitt, Caspi), Duke University, Durham, N.C.; Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand (Ireland, Ramrakha, Poulton); Christchurch Radiology Group, Christchurch, New Zealand (Keenan); Department of Medicine, University of Otago, Christchurch (Melzer); New Zealand Brain Research Institute, Christchurch (Melzer); Social, Genetic, and Developmental Psychiatry Research Center, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Moffitt, Caspi); and McLean Hospital/Harvard Medical School, Belmont, Mass. (Romer).
Terrie E MoffittLaboratory of NeuroGenetics (Romer, Elliott, Knodt, Sison, Hariri), Department of Psychology and Neuroscience (Romer, Knodt, Houts, Moffitt, Caspi, Hariri), Department of Psychiatry and Behavioral Sciences (Moffitt, Caspi), and Center for Genomic and Computational Biology (Moffitt, Caspi), Duke University, Durham, N.C.; Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand (Ireland, Ramrakha, Poulton); Christchurch Radiology Group, Christchurch, New Zealand (Keenan); Department of Medicine, University of Otago, Christchurch (Melzer); New Zealand Brain Research Institute, Christchurch (Melzer); Social, Genetic, and Developmental Psychiatry Research Center, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Moffitt, Caspi); and McLean Hospital/Harvard Medical School, Belmont, Mass. (Romer).
Avshalom CaspiLaboratory of NeuroGenetics (Romer, Elliott, Knodt, Sison, Hariri), Department of Psychology and Neuroscience (Romer, Knodt, Houts, Moffitt, Caspi, Hariri), Department of Psychiatry and Behavioral Sciences (Moffitt, Caspi), and Center for Genomic and Computational Biology (Moffitt, Caspi), Duke University, Durham, N.C.; Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand (Ireland, Ramrakha, Poulton); Christchurch Radiology Group, Christchurch, New Zealand (Keenan); Department of Medicine, University of Otago, Christchurch (Melzer); New Zealand Brain Research Institute, Christchurch (Melzer); Social, Genetic, and Developmental Psychiatry Research Center, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Moffitt, Caspi); and McLean Hospital/Harvard Medical School, Belmont, Mass. (Romer).
Ahmad R HaririLaboratory of NeuroGenetics (Romer, Elliott, Knodt, Sison, Hariri), Department of Psychology and Neuroscience (Romer, Knodt, Houts, Moffitt, Caspi, Hariri), Department of Psychiatry and Behavioral Sciences (Moffitt, Caspi), and Center for Genomic and Computational Biology (Moffitt, Caspi), Duke University, Durham, N.C.; Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand (Ireland, Ramrakha, Poulton); Christchurch Radiology Group, Christchurch, New Zealand (Keenan); Department of Medicine, University of Otago, Christchurch (Melzer); New Zealand Brain Research Institute, Christchurch (Melzer); Social, Genetic, and Developmental Psychiatry Research Center, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Moffitt, Caspi); and McLean Hospital/Harvard Medical School, Belmont, Mass. (Romer).
Funding
Quantifying Individual Differences in Midlife Structural Brain Integrity Associated with Later AD/ADRD RiskR01AG049789 · NIA · DUKE UNIVERSITY · PI AHMAD R. HARIRI, TERRIE E MOFFITT · 2015 to 2026
$10.6MIs mental disorder a preventable cause of age-related disease? The Dunedin Study.R01AG032282 · NIA · DUKE UNIVERSITY · PI CASPI, AVSHALOM, MOFFITT, TERRIE E · 2009 to 2025
$9.5MReplicability, Mechanisms, and Trajectory of Neural Alterations Related to General PsychopathologyF32MH124409 · NIMH · MCLEAN HOSPITAL · PI ROMER, ADRIENNE LYNN · 2020 to 2022
$210kMedical Research Council MR/P005918/1NIA NIH HHS R01 AG032282NIA NIH HHS R01 AG049789NIMH NIH HHS F32 MH124409
Abstract
objectiveNeuroimaging research has revealed that structural brain alterations are common across broad diagnostic families of disorders rather than specific to a single psychiatric disorder. Such overlap in the structural brain correlates of mental disorders mirrors already well-documented phenotypic comorbidity of psychiatric symptoms and diagnoses, which can be indexed by a general psychopathology or
methodsAnalyses were conducted on structural MRI and psychopathology data collected from 861 members of the population-representative Dunedin Multidisciplinary Health and Development Study at age 45.
resultsStudy members with high scores across three broad diagnostic families of disorders (externalizing, internalizing, thought disorder) exhibited highly overlapping patterns of reduced global and widely distributed parcel-wise neocortical thickness. Study members with high
conclusionsA pattern of pervasively reduced neocortical thickness appears to be common across all forms of mental disorders and may represent a transdiagnostic feature of general psychopathology. As has been documented with regard to symptoms and diagnoses, the underlying brain structural correlates of mental disorders may not exhibit specificity, and the continued pursuit of such specific correlates may limit progress toward more effective strategies for etiological understanding, prevention, and intervention.
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AdolescentAdultChildChild, PreschoolCohort StudiesFemaleHumansMaleMental DisordersMiddle AgedNeocortexPsychopathologyYoung AdultCortical ThicknessGeneral PsychopathologyNeuroimagingp FactorTransdiagnostic
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