Evidence map›Paper›PMID 32599980›Full record

ArticleCancer research and treatment2020

Nomogram for Predicting Central Lymph Node Metastasis in Papillary Thyroid Cancer: A Retrospective Cohort Study of Two Clinical Centers.

Zheyu Yang, Yu Heng, Jianwei Lin, Chenghao Lu, Dingye Yu, Lei Tao, Wei Cai

Open access · diamondAbstract readMulticenter StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer research and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zheyu YangDepartment of General Surgery, Shanghai Jiaotong University School of Medicine Affiliated Ruijin Hospital, Shanghai, China.
Yu HengENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Jianwei LinDepartment of General Surgery, Shanghai Jiaotong University School of Medicine Affiliated Ruijin Hospital, Shanghai, China.
Chenghao LuDepartment of General Surgery, Shanghai Jiaotong University School of Medicine Affiliated Ruijin Hospital, Shanghai, China.
Dingye YuDepartment of General Surgery, Shanghai Jiaotong University School of Medicine Affiliated Ruijin Hospital, Shanghai, China.
Lei TaoENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Wei CaiDepartment of General Surgery, Shanghai Jiaotong University School of Medicine Affiliated Ruijin Hospital, Shanghai, China.
Ruijin Hospital · CNEye & ENT Hospital of Fudan University · CN

Funding

Shanghai Jiaotong University YG2019ZDA15Shanghai Municipal Science and Technology Commission 19441905400
6 · The paper itself

Abstract

purposeCentral lymph node metastasis (CNM) are highly prevalent but hard to detect preoperatively in papillary thyroid carcinoma (PTC) patients, while the significance of prophylactic compartment central lymph node dissection (CLND) remains controversial as a treatment option. We aim to establish a nomogram assessing risks of CNM in PTC patients, and explore whether prophylactic CLND should be recommended. MATERIALS AND

methodsOne thousand four hundred thirty-eight patients from two clinical centers that underwent thyroidectomy with CLND for PTC within the period 2016-2019 were retrospectively analyzed. Univariate and multivariate analysis were performed to examine risk factors associated with CNM. A nomogram for predicting CNM was established, thereafter internally and externally validated.

resultsSeven variables were found to be significantly associated with CNM and were used to construct the model. These were as follows: thyroid capsular invasion, multifocality, creatinine > 70 μmol/L, age < 40, tumor size > 1 cm, body mass index < 22, and carcinoembryonic antigen > 1 ng/mL. The nomogram had good discrimination with a concordance index of 0.854 (95% confidence interval [CI], 0.843 to 0.867), supported by an external validation point estimate of 0.825 (95% CI, 0.793 to 0.857). A decision curve analysis was made to evaluate nomogram and ultrasonography for predicting CNM.

conclusionA validated nomogram utilizing readily available preoperative variables was developed to predict the probability of central lymph node metastases in patients presenting with PTC. This nomogram may help surgeons make appropriate surgical decisions in the management of PTC, especially in terms of whether prophylactic CLND is warranted.

Indexed as

NomogramsAdolescentAdultAgedClinical Decision-MakingFemaleHumansLymphatic MetastasisLymph Node ExcisionLymph NodesMaleMiddle AgedPreoperative PeriodProphylactic Surgical ProceduresRetrospective StudiesRisk AssessmentCentral lymph node metastasisNomogramsPapillary thyroid cancerRisk factors

Identifiers

PMID32599980
PMCPMC7577812
OpenAlexW3034651100

What OpenQuestion holds

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LicenceCC BY-NC
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.