Evidence map›Paper›PMID 32599915›Full record

ArticleInternational journal of molecular sciences2020

Identification of Brain-Specific Treatment Effects in NPC1 Disease by Focusing on Cellular and Molecular Changes of Sphingosine-1-Phosphate Metabolism.

Anne Gläser, Franziska Hammerl, Markus H Gräler, Sina M Coldewey, Christin Völkner, Moritz J Frech, Fan Yang, Jiankai Luo, Eric Tönnies, Oliver von Bohlen Und Halbach and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Understanding and Treating Niemann-Pick Type C Disease: Models Matter.International journal of molecular sciences · 2020
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 1 country.

Anne GläserResearch Group Anatomy, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26129 Oldenburg, Germany.
Franziska HammerlResearch Group Anatomy, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26129 Oldenburg, Germany.
Markus H GrälerDepartment of Anaesthesiology and Intensive Care Medicine, Center for Sepsis Control and Care (CSCC), Center for Molecular Biomedicine (CMB), Jena University Hospital, 07745 Jena, Germany.ORCID 0000-0001-6650-7849
Sina M ColdeweyDepartment of Anaesthesiology and Intensive Care Medicine, Septomics Research Center, Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany.
Christin VölknerTranslational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany.
Moritz J FrechTranslational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany.ORCID 0000-0003-2421-8779
Fan YangTranslational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany.
Jiankai LuoTranslational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany.
Eric TönniesInstitute of Anatomy and Cell Biology, University Medicine Greifswald, 17487 Greifswald, Germany.
Oliver von Bohlen Und HalbachInstitute of Anatomy and Cell Biology, University Medicine Greifswald, 17487 Greifswald, Germany.ORCID 0000-0002-6265-9156
Nicola BrandtResearch Group Anatomy, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26129 Oldenburg, Germany.
Diana HeimesInstitute of Anatomy, Rostock University Medical Center, 18057 Rostock, Germany.
Anna-Maria NeßlauerInstitute of Anatomy, Rostock University Medical Center, 18057 Rostock, Germany.
Georg Christoph KorenkeDepartment of Pediatrics, Klinikum Oldenburg, 26133 Oldenburg, Germany.
Marta Owczarek-LipskaHuman Genetics, School of Medicine and Health Sciences, University of Oldenburg, 26129 Oldenburg, Germany.
John NeidhardtHuman Genetics, School of Medicine and Health Sciences, University of Oldenburg, 26129 Oldenburg, Germany.
Arndt RolfsCentogene AG, D-18055 Rostock, Germany.
Andreas WreeInstitute of Anatomy, Rostock University Medical Center, 18057 Rostock, Germany.
Martin WittInstitute of Anatomy, Rostock University Medical Center, 18057 Rostock, Germany.ORCID 0000-0002-4538-877X
Anja Ursula BräuerResearch Group Anatomy, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26129 Oldenburg, Germany.ORCID 0000-0003-3651-1470
University of Rostock · DECarl von Ossietzky Universität Oldenburg · DEJena University Hospital · DEUniversitätsmedizin Greifswald · DECentogene (Germany) · DEKlinikum Oldenburg · DE

Funding

Bundesministerium für Bildung und Forschung 03Z22JN12 to SCImpuls Forschung, Verbund Norddeutscher Universitäten A.U.B. and M.J.F.Impuls Forschung, Verbund Norddeutscher Universitäten O.V. and A.U.B.
6 · The paper itself

Abstract

Niemann-Pick type C1 (NPC1) is a lysosomal storage disorder, inherited as an autosomal-recessive trait. Mutations in the

Indexed as

Disease Models, AnimalMutation1-DeoxynojirimycinAdultAnimalsBrainGlycoside Hydrolase InhibitorsHumansInduced Pluripotent Stem CellsIntracellular Signaling Peptides and ProteinsLysophospholipidsMiceMice, KnockoutNiemann-Pick C1 ProteinNiemann-Pick Disease, Type CSphingosine1-DeoxynojirimycinGlycoside Hydrolase InhibitorsIntracellular Signaling Peptides and ProteinsLysophospholipidsmiglustatNiemann-Pick C1 ProteinNpc1 protein, mouseSphingosinesphingosine 1-phosphatebrainfibroblastsHPTLCmass spectrometryNiemann–Pick disease type C1qRT-PCRS1Psphingolipidssphingosine-1-phosphate receptorswhite matter

Identifiers

PMID32599915
PMCPMC7352403
OpenAlexW3038094248

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.