Evidence map›Paper›PMID 32599898›Full record

ArticleMolecules (Basel, Switzerland)2020

Targeting the Protein Tunnels of the Urease Accessory Complex: A Theoretical Investigation.

Matteo Masetti, Federico Falchi, Dario Gioia, Maurizio Recanatini, Stefano Ciurli, Francesco Musiani

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Ozone-Assisted Green Upgrading ofFoods (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matteo MasettiLaboratory of Computational Medicinal Chemistry, Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-3757-7802
Federico FalchiLaboratory of Computational Medicinal Chemistry, Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0001-7385-649X
Dario GioiaComputational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.ORCID 0000-0003-0560-1799
Maurizio RecanatiniLaboratory of Computational Medicinal Chemistry, Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-0039-0518
Stefano CiurliLaboratory of Bioinorganic Chemistry, Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0001-9557-926X
Francesco MusianiLaboratory of Bioinorganic Chemistry, Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0003-0200-1712

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urease is a nickel-containing enzyme that is essential for the survival of several and often deadly pathogenic bacterial strains, including

Indexed as

Bacterial ProteinsBinding SitesDrug Evaluation, PreclinicalEnzyme InhibitorsHelicobacter pyloriMolecular Dynamics SimulationMultiprotein ComplexesPhosphate-Binding ProteinsSmall Molecule LibrariesUreaseBacterial ProteinsEnzyme InhibitorsMultiprotein ComplexesPhosphate-Binding ProteinsSmall Molecule LibrariesUreaseUreD protein, BacteriaUreF protein, bacteriaureG protein, BacteriaHelicobacter pyloriprotein–protein interactionprotein tunnelsureasevirtual screening

Identifiers

PMID32599898
PMCPMC7355429

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.