Evidence map›Paper›PMID 32599789›Full record

ArticleCancers2020

Neuroprotection of Radiosensitive Juvenile Mice by Ultra-High Dose Rate FLASH Irradiation.

Yasaman Alaghband, Samantha N Cheeks, Barrett D Allen, Pierre Montay-Gruel, Ngoc-Lien Doan, Benoit Petit, Patrik Goncalves Jorge, Erich Giedzinski, Munjal M Acharya, Marie-Catherine Vozenin and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 5 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 5 syntheses or guidelines pooled it, 131 citations in OpenAlex.

  1. Pooled it
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  5. The current status of FLASH particle therapy: a systematic review.Physical and engineering sciences in medicine · 2023
    Pooled it
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  20. Microenvironmental remodeling in FLASH radiotherapy.Frontiers in cell and developmental biology · 2026
    Review

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Yasaman AlaghbandDepartment of Radiation Oncology, University of California, Irvine, CA 92697, USA.
Samantha N CheeksDepartment of Radiation Oncology, University of California, Irvine, CA 92697, USA.
Barrett D AllenDepartment of Radiation Oncology, University of California, Irvine, CA 92697, USA.
Pierre Montay-GruelDepartment of Radiation Oncology, University of California, Irvine, CA 92697, USA.
Ngoc-Lien DoanDepartment of Radiation Oncology, University of California, Irvine, CA 92697, USA.
Benoit PetitLaboratory of Radiation Oncology, Department of Radiation Oncology, Lausanne University Hospital and University of Lausanne, 1000 Lausanne, Switzerland.
Patrik Goncalves JorgeLaboratory of Radiation Oncology, Department of Radiation Oncology, Lausanne University Hospital and University of Lausanne, 1000 Lausanne, Switzerland.
Erich GiedzinskiDepartment of Radiation Oncology, University of California, Irvine, CA 92697, USA.
Munjal M AcharyaDepartment of Radiation Oncology, University of California, Irvine, CA 92697, USA.
Marie-Catherine VozeninLaboratory of Radiation Oncology, Department of Radiation Oncology, Lausanne University Hospital and University of Lausanne, 1000 Lausanne, Switzerland.ORCID 0000-0002-2109-8073
Charles L LimoliDepartment of Radiation Oncology, University of California, Irvine, CA 92697, USA.
University of California, Irvine · USUniversity of Lausanne · CHInstitute of Radiation Physics

Funding

Institutional Career Development CoreKL2TR001416 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, DEMETRIOU, MICHAEL · 2015 to 2023
$5.6M
Mechanisms underlying radiation-and chemotherapy induced cognitive impairment.R01NS089575 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIMOLI, CHARLES · 2015 to 2020
$2.8M
NCATS NIH HHS KL2 TR001416NINDS NIH HHS NS089575undefined <span style="color:gray;font-size:10px;">undefined</span> Synergia grant from the FNS CRS II5_186369
6 · The paper itself

Abstract

Major advances in high precision treatment delivery and imaging have greatly improved the tolerance of radiotherapy (RT); however, the selective sparing of normal tissue and the reduction of neurocognitive side effects from radiation-induced toxicities remain significant problems for pediatric patients with brain tumors. While the overall survival of pediatric patients afflicted with medulloblastoma (MB), the most common type primary brain cancer in children, remains high (≥80%), lifelong neurotoxic side-effects are commonplace and adversely impact patients' quality of life. To circumvent these clinical complications, we have investigated the capability of ultra-high dose rate FLASH-radiotherapy (FLASH-RT) to protect the radiosensitive juvenile mouse brain from normal tissue toxicities. Compared to conventional dose rate (CONV) irradiation, FLASH-RT was found to ameliorate radiation-induced cognitive dysfunction in multiple independent behavioral paradigms, preserve developing and mature neurons, minimize microgliosis and limit the reduction of the plasmatic level of growth hormone. The protective "FLASH effect" was pronounced, especially since a similar whole brain dose of 8 Gy delivered with CONV-RT caused marked reductions in multiple indices of behavioral performance (objects in updated location, novel object recognition, fear extinction, light-dark box, social interaction), reductions in the number of immature (doublecortin

Indexed as

cognitive dysfunctionFLASH radiotherapyjuvenile micemedulloblastomamemory consolidationneurogenesispediatric brain cancerupdating task

Identifiers

PMID32599789
PMCPMC7352849
OpenAlexW3037264706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.