Evidence map›Paper›PMID 32599724›Full record

ArticleBiomolecules2020

The Citrus Flavonoid Hesperetin Has an Inadequate Anti-Arrhythmic Profile in the ΔKPQ Na

Julio Alvarez-Collazo, Alejandro López-Requena, Julio L Alvarez, Karel Talavera

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Julio Alvarez-CollazoLaboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven, VIB Center for Brain & Disease Research, 3000 Leuven, Belgium.
Alejandro López-RequenaLaboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven, VIB Center for Brain & Disease Research, 3000 Leuven, Belgium.ORCID 0000-0002-6951-8321
Julio L AlvarezLaboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven, VIB Center for Brain & Disease Research, 3000 Leuven, Belgium.
Karel TalaveraLaboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven, VIB Center for Brain & Disease Research, 3000 Leuven, Belgium.ORCID 0000-0002-3124-138X
VIB-KU Leuven Center for Brain & Disease Research · BE

Funding

Fonds Wetenschappelijk Onderzoek G.0765.13Onderzoeksraad, KU Leuven GOA/14/011 and C14/18/086
6 · The paper itself

Abstract

Type 3 long QT syndromes (LQT3) are associated with arrhythmogenic gain-of-function mutations in the cardiac voltage-gated Na

Indexed as

Anti-Arrhythmia AgentsCardiac Conduction System DiseaseCells, CulturedCitrusDose-Response Relationship, DrugHEK293 CellsHesperidinHumansLong QT SyndromeMutationNAV1.5 Voltage-Gated Sodium ChannelAnti-Arrhythmia AgentshesperetinHesperidinNAV1.5 Voltage-Gated Sodium Channelcitrusflavonoidgenetic varianthesperetinhuman cardiac Na+ channellong QT type 3 syndromemutantNaV1.5precision medicineΔKPQ

Identifiers

PMID32599724
PMCPMC7355927
OpenAlexW3038026297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.