ArticleMolecular plant pathology2020
Ralstonia solanacearum promotes pathogenicity by utilizing l-glutamic acid from host plants.
Article in Molecular plant pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 56 citations in OpenAlex.
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- The Influence of Pre-Harvest Application ofFoods (Basel, Switzerland) · 2026Article
- Analysis of Bacterial Wilt Management Strategies From the Dynamic Perspective of Environmental Adaptation Approaches of Ralstonia solanacearum.Environmental microbiology reports · 2026Review
- Molecular regulation of functions ofPlant biotechnology (Tokyo, Japan) · 2025Article
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- Root exudate monosaccharides modulate the pathogenicity ofFrontiers in microbiology · 2025Article
- Strategies utilized by plants to defend againstFrontiers in plant science · 2025Review
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- The transcription regulator ChpA affects the global transcriptome including quorum sensing-dependent genes in Ralstonia pseudosolanacearum strain OE1-1.Molecular plant pathology · 2023Article
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- Anti-Virulence Strategy of Novel Dehydroabietic Acid Derivatives: Design, Synthesis, and Antibacterial Evaluation.International journal of molecular sciences · 2023Article
- Induced defense strategies of plants againstFrontiers in microbiology · 2023Review
- Pulmonary microbiota signatures adjacent to adenocarcinoma, squamous cell carcinoma and benign lesion.Frontiers in oncology · 2023Article
- RasI/R Quorum Sensing System Controls the Virulence ofApplied and environmental microbiology · 2022Article
- Genome Sequence of Ralstonia pseudosolanacearum SL1931, a Causal Phytopathogen of Bacterial Wilt Disease in Capsicum annuum and Nicotiana benthamiana.Microbiology resource announcements · 2022Article
- QTL Mapping for Resistance to Bacterial Wilt Caused by Two Isolates ofPlants (Basel, Switzerland) · 2022Article
- Proline utilization A controls bacterial pathogenicity by sensing its substrate and cofactors.Communications biology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ralstonia solanacearum is an important bacterial pathogen that can infect a broad range of plants worldwide. A previous study showed that R. solanacearum could respond to exogenous organic acids or amino acids to modulate cell motility. However, it was unclear whether R. solanacearum uses these compounds to control infection. In this study, we found that R. solanacearum GMI1000 uses host plant metabolites to enhance the biosynthesis of virulence factors. We demonstrated that l-glutamic acid from host plants is the key active component associated with increased extracellular polysaccharide production, cellulase activity, swimming motility, and biofilm formation in R. solanacearum GMI1000. In addition, l-glutamic acid also promoted colonization of R. solanacearum cells in the roots and stems of tomato plants and accelerated disease incidence. Furthermore, genetic screening and biochemical analysis suggested that RS01577, a hybrid sensor histidine kinase/response regulator, is involved in l-glutamic acid signalling in R. solanacearum. Mutations in RS01577 and exogenous addition of l-glutamic acid to the GMI1000 wild-type strain had overlapping effects on both the transcriptome and biological functions of R. solanacearum, including on motility, biofilm formation, and virulence. Thus, our results have established a new interaction mechanism between R. solanacearum and host plants that highlights the complexity of the virulence regulation mechanism and may provide new insight into disease control.
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