Evidence map›Paper›PMID 32599521›Full record

ReviewCurrent opinion in microbiology2020

Minority report: the intestinal mycobiota in systemic infections.

Thierry Rolling, Tobias M Hohl, Bing Zhai

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Detection of Fungal Translocation in Patients With Alcohol Use Disorder Using a Real-Time PCR Assay.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026
    Article
  7. Article
  8. Article
  9. The Human Mycobiome.Current topics in microbiology and immunology · 2025
    Review
  10. Review
  11. Article
  12. Article
  13. Alterations of the Intestinal Mucosal Barrier and Gut Fungal Microbiome in Asymptomatic HIV-Infected Patients.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. COVID-19 and Fungal Diseases.Antibiotics (Basel, Switzerland) · 2022
    Review
  20. Antifungal Activity of the Frog Skin Peptide Temporin G and Its Effect onInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Thierry RollingInfectious Disease Service, Department of Medicine, Memorial Hospital, New York, NY, USA; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: rollingt@mskcc.org.
Tobias M HohlInfectious Disease Service, Department of Medicine, Memorial Hospital, New York, NY, USA; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Bing ZhaiInfectious Disease Service, Department of Medicine, Memorial Hospital, New York, NY, USA; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: zhaib@mskcc.org.
Memorial Sloan Kettering Cancer Center · USMemorial Hospital · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
INITIATION OF THE IMMUNE RESPONSE TO ASPERGILLUS FUMIGATUSR01AI093808 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI HOHL, TOBIAS M · 2011 to 2020
$4.9M
INITIATION OF THE IMMUNE RESPONSE TO ASPERGILLUS FUMIGATUSR37AI093808 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI TOBIAS M HOHL · 2021 to 2026
$4.2M
Antifungal Immunity and the Mechanism of Fungal Programmed Cell DeathR01AI139632 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI CRAMER, ROBERT ANDREW, HOHL, TOBIAS M · 2019 to 2023
$3.3M
Dissecting the role of Bruton's tyrosine kinase and ibrutinib in fungal immune surveillanceR21AI142639 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI HOHL, TOBIAS M · 2019 to 2020
$494k
NCI NIH HHS P30 CA008748NIAID NIH HHS R01 AI093808NIAID NIH HHS R01 AI139632NIAID NIH HHS R21 AI142639NIAID NIH HHS R37 AI093808
6 · The paper itself

Abstract

Compared to bacteria, fungi often exhibit a lower abundance and a higher temporal volatility in the intestinal microbiota. Analysis of fungi in the microbiota (mycobiota) faces technical limitations with tools that were originally developed for analyzing bacteria. Dysbiotic states of the intestinal mycobiota, often associated with disruption of the healthy bacterial microbiota, are characterized by overgrowth (domination) of specific fungal taxa and loss of diversity. Intestinal domination by Candida species has been shown to be a major source of Candida bloodstream infections. Fungal dysbiosis is also linked to the development and treatment response in non-fungal infections, for example Clostridioides difficile colitis and HIV. Further research is needed to define the contribution of intestinal mycobiota to human fungal and non-fungal infections.

Indexed as

Gastrointestinal MicrobiomeAnimalsBacteriaBacterial Physiological PhenomenaDysbiosisFungiHumansIntestines

Identifiers

PMID32599521
PMCPMC7744423
OpenAlexW3038007809

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.