Evidence map›Paper›PMID 32599360›Full record

ArticleBiomaterials2020

Localized mandibular infection affects remote in vivo bioreactor bone generation.

Emma Watson, Brandon T Smith, Mollie M Smoak, Alexander M Tatara, Sarita R Shah, Hannah A Pearce, Katie J Hogan, Jonathan Shum, James C Melville, Issa A Hanna and 7 more

Open access · greenAbstract read
In one paragraph

Article in Biomaterials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. [Research progress ofZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2021
    Review
  10. An Ovine Model ofTissue engineering. Part C, Methods · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Emma WatsonDepartment of Bioengineering, Rice University, Houston, TX, USA; Medical Scientist Training Program, Baylor College of Medicine, Houston, TX, USA.
Brandon T SmithDepartment of Bioengineering, Rice University, Houston, TX, USA; Medical Scientist Training Program, Baylor College of Medicine, Houston, TX, USA.
Mollie M SmoakDepartment of Bioengineering, Rice University, Houston, TX, USA.
Alexander M TataraDepartment of Bioengineering, Rice University, Houston, TX, USA; Medical Scientist Training Program, Baylor College of Medicine, Houston, TX, USA.
Sarita R ShahDepartment of Bioengineering, Rice University, Houston, TX, USA; Medical Scientist Training Program, Baylor College of Medicine, Houston, TX, USA.
Hannah A PearceDepartment of Bioengineering, Rice University, Houston, TX, USA.
Katie J HoganDepartment of Bioengineering, Rice University, Houston, TX, USA; Medical Scientist Training Program, Baylor College of Medicine, Houston, TX, USA.
Jonathan ShumDepartment of Oral and Maxillofacial Surgery, The University of Texas Health Science Center at Houston, Houston, TX, USA.
James C MelvilleDepartment of Oral and Maxillofacial Surgery, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Issa A HannaDepartment of Oral and Maxillofacial Surgery, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Nagi DemianDepartment of Oral and Maxillofacial Surgery, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Joseph C WenkeExtremity Trauma & Regenerative Medicine, U.S. Army Institute of Surgical Research, San Antonio, TX, USA.
George N BennettDepartment of Biosciences, Rice University, Houston, TX, USA.
Jeroen J J P van den BeuckenDepartment of Biomaterials, Radboudumc, Nijmegen, the Netherlands.
John A JansenDepartment of Biomaterials, Radboudumc, Nijmegen, the Netherlands.
Mark E WongDepartment of Oral and Maxillofacial Surgery, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Antonios G MikosDepartment of Bioengineering, Rice University, Houston, TX, USA. Electronic address: mikos@rice.edu.
Baylor College of Medicine · USThe University of Texas Health Science Center at Houston · USRice University · USRadboud University Nijmegen · NLUnited States Army Institute of Surgical Research · US

Funding

Training and Dissemination CoreP41EB023833 · NIBIB · UNIV OF MARYLAND, COLLEGE PARK · PI MIKOS, ANTONIOS G. · 2017 to 2021
$6.2M
Rapidly-Degrading Calcium Phosphate Cements for Orthopedic Tissue Engineering.F30AR071258 · NIAMS · RICE UNIVERSITY · PI SMITH, BRANDON · 2017 to 2020
$168k
3D-Printed Demineralized Bone Matrix Hydrogels for Craniofacial Bone Tissue Regeneration.F31DE030333 · NIDCR · RICE UNIVERSITY · PI HOGAN, KATIE · 2020 to 2022
$141k
"A Two-Stage High-Fidelity, Anti-Infective Approach to Craniofacial Repair in Novel Ovine Model"F31DE027586 · NIDCR · RICE UNIVERSITY · PI WATSON, EMMA · 2017 to 2019
$134k
NIAMS NIH HHS F30 AR071258NIBIB NIH HHS P41 EB023833NIDCR NIH HHS F31 DE027586NIDCR NIH HHS F31 DE030333
6 · The paper itself

Abstract

Mandibular reconstruction requires functional and aesthetic repair and is further complicated by contamination from oral and skin flora. Antibiotic-releasing porous space maintainers have been developed for the local release of vancomycin and to promote soft tissue attachment. In this study, mandibular defects in six sheep were inoculated with 10

Indexed as

MandibleMandibular ReconstructionAnimalsAnti-Bacterial AgentsBioreactorsPorosityProstheses and ImplantsSheepAnti-Bacterial AgentsIn vivo bioreactorsLarge animal modelLocal antibiotic releaseMandibular repairOsteomyelitisTissue engineering

Identifiers

PMID32599360
PMCPMC7423761
OpenAlexW3038105405

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.