ReviewCurrent opinion in genetics & development2020
Regeneration in the spiny mouse, Acomys, a new mammalian model.
Review in Current opinion in genetics & development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Spiny Mice Show a Profibrotic Epicardial Mesothelial Response to Hypoxic Injury Comparable to C57BL/6 Mice.Biomolecules · 2026Article
- Resistance to tumorigenesis in the african spiny mouse (Acomys) correlates with upregulation of multiple tumor suppressor genes.Scientific reports · 2026Article
- Applied Anatomical and Morphological Characterization of the Ocular Surface of the African Spiny Mice: Acomys cahirinus.Investigative ophthalmology & visual science · 2026Article
- Efficacy and Pharmacokinetics of 3 Sustained-Release Buprenorphine Formulations in Cairo Spiny Mice (Acomys cahirinus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Definition of critical skin defect and concepts of structural and functional repairs: Proposal and verification in a rat model.Animal models and experimental medicine · 2026Article
- Ageing versus developmental silencing: Answers from the epigenome.The FEBS journal · 2025Review
- Pharmacokinetic Profiling UsingInternational journal of molecular sciences · 2025Article
- An ear for an ear, but only if you are a deomyinid.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Osteogenic shift in the adipose-derived stem cells ofFrontiers in cell and developmental biology · 2025Article
- The Promise of a Pointillist Perspective for Comparative Immunology.Physiology (Bethesda, Md.) · 2024Review
- Retinal neuroanatomy of two emerging model organisms, the spiny mouse (Acomys dimidiatus) and the Mongolian gerbil (Meriones unguiculatus).Experimental eye research · 2024Article
- Inner Structure of the Lateral Geniculate Complex of Adult and NewbornInternational journal of molecular sciences · 2024Article
- Comparative biology and non-traditional approaches for basic aging research for facilitating translational studies.GeroScience · 2024Article
- Effects of High-protein and High-fiber Diets on Weight and Glucose Regulation in Spiny Mice (Journal of the American Association for Laboratory Animal Science : JAALAS · 2024Article
- Osteoderms in a mammal the spiny mouseiScience · 2023Article
- Preclinical Models and Promising Pharmacotherapeutic Strategies in Liver Fibrosis: An Update.Current issues in molecular biology · 2023Review
- Comparative analysis of Acomys cahirinus and Mus musculus responses to genotoxicity, oxidative stress, and inflammation.Scientific reports · 2023Article
- Genital Wound Repair and Scarring.Medical sciences (Basel, Switzerland) · 2022Review
- Tumor suppressors inhibit reprogramming of African spiny mouse (Wellcome open research · 2022Article
- Revelations About Aging and Disease from Unconventional Vertebrate Model Organisms.Annual review of genetics · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We describe the tissues and organs that show exceptional regenerative ability following injury in the spiny mouse, Acomys. The skin and ear regenerate: hair and its associated stem cell niches, sebaceous glands, dermis, adipocytes, cartilage, smooth muscle, and skeletal muscle. Internal tissues such as the heart, kidney, muscle, and spinal cord respond to damage by showing significantly reduced inflammation and improved regeneration responses. The reason for this improved ability may lie in the immune system which shows a blunted inflammatory response to injury compared to that of the typical mammal, but we also show that there are distinct biomechanical properties of Acomys tissues. Examining the regenerative behavior of closely related mammals may provide insights into the evolution of this remarkable property.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.