Evidence map›Paper›PMID 32599096›Full record

ReviewTranslational research : the journal of laboratory and clinical medicine2020

Hormones and thrombosis: risk across the reproductive years and beyond.

Nicoletta Machin, Margaret V Ragni

Open access · greenAbstract readReview
In one paragraph

Review in Translational research : the journal of laboratory and clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Hibiscus Tea, Hormone Balance, and Thrombosis: A Case Report.Integrative medicine (Encinitas, Calif.) · 2023
    Article
  7. Systemic hormonal contraception and risk of venous thromboembolism.Acta obstetricia et gynecologica Scandinavica · 2022
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Nicoletta MachinDepartment of Medicine, Division of Hematology/Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Hemophilia Center of Western Pennsylvania, Pittsburgh, Pennsylvania.
Margaret V RagniDepartment of Medicine, Division of Hematology/Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Hemophilia Center of Western Pennsylvania, Pittsburgh, Pennsylvania. Electronic address: ragni@pitt.edu.
Hemophilia Center of Western Pennsylvania · USUniversity of Pittsburgh Medical Center · US

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
WITHIN SUBJ VARIABILITY IN MEASUREMENTS DRUG METABOL ENZYMES IN HLTY SUBJM01RR000056 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEVINE, ARTHUR S · 1985 to 2006
$29.2M
Zimmerman Program for the Molecular and Clinical Biology of VWDP01HL081588 · NHLBI · VERSITI WISCONSIN, INC. · PI MONTGOMERY, ROBERT R · 2005 to 2016
$19.3M
Comparative Effectiveness in the Diagnosis of VWDR01HL112614 · NHLBI · VERSITI WISCONSIN, INC. · PI ABSHIRE, THOMAS CALVIN, MONTGOMERY, ROBERT R · 2013 to 2018
$4.1M
Mentored career development in clinical research in non-malignant hematologyK12HL087064 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ABRAMS, CHARLES S. · 2006 to 2016
$3.9M
Von Willebrand Disease Minimize Menorrhagia (VWDMin) TrialU01HL133815 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAGNI, MARGARET VICTORIA · 2017 to 2021
$2.8M
Impact of HIV on Hepatitis C Infection in HemophiliaR01HL068429 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAGNI, MARGARET VICTORIA · 2001 to 2004
$1.8M
University of Pittsburgh Clinical and Translational Science InstituteTL1RR024155 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$1.8M
Design of Less Immunogenic Factor VIII ProteinsR01HL130448 · NHLBI · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI PRATT, KATHLEEN PALMER · 2016 to 2019
$1.5M
Hemophilia Adult Prophylaxis StudyR34HL105870 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAGNI, MARGARET VICTORIA · 2011 to 2012
$771k
Feasibility of the Hemophilia INHIBIT TrialU34HL114674 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAGNI, MARGARET VICTORIA · 2012 to 2013
$715k
NCATS NIH HHS UL1 TR000005NCRR NIH HHS M01 RR000056NCRR NIH HHS TL1 RR024155NCRR NIH HHS UL1 RR024153NHLBI NIH HHS K12 HL087064NHLBI NIH HHS P01 HL081588NHLBI NIH HHS R01 HL061937NHLBI NIH HHS R01 HL068429NHLBI NIH HHS R01 HL112614NHLBI NIH HHS R34 HL105870NHLBI NIH HHS T35 HL074708NHLBI NIH HHS U01 HL133815NHLBI NIH HHS U34 HL114674NHLBI NIH HHS U34 HL119582
6 · The paper itself

Abstract

Endogenous and exogenous hormones have significant effects on coagulation and may tip the hemostatic balance toward thrombosis. The endogenous hormonal changes in pregnancy and polycystic ovary syndrome, and exogenous hormonal contraception, menopause replacement, and transgender cross-hormone replacement may increase thromboembolism risk. Using the lowest effective dose is critical for prevention, but once thrombosis occurs, anticoagulation may be required, in some, long term. We review the relative risk of thrombosis in these conditions, risk factors, and anticoagulation treatment and prevention. Implementation of lowest effective hormonal therapies, thrombosis reduction strategies, and current anticoagulation management are critical for optimal patient outcomes.

Indexed as

ReproductionHormonesHumansRisk FactorsThrombosisHormones

Identifiers

PMID32599096
PMCPMC11867114
OpenAlexW3037287902

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.