Evidence map›Paper›PMID 32598563›Full record

ArticleESC heart failure2020

Ethnic differences in association of outcomes with trimethylamine N-oxide in acute heart failure patients.

Yoshiyuki Yazaki, Kenichi Aizawa, Muhammad Zubair Israr, Keita Negishi, Andrea Salzano, Yuka Saitoh, Natsuka Kimura, Ken Kono, Liam Heaney, Shabana Cassambai and 7 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 4 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Effects of Weight Loss Interventions on Gut Microbiota-Derived Metabolites Linked to Cardiometabolic Health: A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Yoshiyuki YazakiDepartment of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Leicester, UK.
Kenichi AizawaDivision of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi, Japan.
Muhammad Zubair IsrarDepartment of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Leicester, UK.
Keita NegishiDivision of Cardiovascular Medicine, Department of Medicine, Jichi Medical University, Tochigi, Japan.
Andrea SalzanoDiagnostic and Nuclear Research Institute, IRCCS SDN, Naples, Italy.
Yuka SaitohDivision of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi, Japan.
Natsuka KimuraDivision of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi, Japan.
Ken KonoDivision of Cardiovascular Medicine, Department of Medicine, Jichi Medical University, Tochigi, Japan.
Liam HeaneyDepartment of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Leicester, UK.
Shabana CassambaiDepartment of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Leicester, UK.
Dennis BerniehDepartment of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Leicester, UK.
Florence LaiDepartment of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Leicester, UK.
Yasushi ImaiDivision of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi, Japan.
Kazuomi KarioDivision of Cardiovascular Medicine, Department of Medicine, Jichi Medical University, Tochigi, Japan.
Ryozo NagaiJichi Medical University, Tochigi, Japan.
Leong L NgDepartment of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Leicester, UK.
Toru SuzukiDepartment of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Leicester, UK.
Jichi Medical University · JPNIHR Leicester Biomedical Research Centre · GBJichi Medical University Hospital · JPNIHR Leicester Cardiovascular Biomedical Research Unit · GBUniversity of Leicester · GBSDN Istituto di Ricerca Diagnostica e Nucleare · IT

Funding

Grants-in-Aid for Scientific Research in Priority Areas 16H05115Japan Agency for Medical Research and Development (AMED) 17ek0210011h0005
6 · The paper itself

Abstract

aimsThe aim of this study was to investigate whether ethnicity influences the associations between trimethylamine N-oxide (TMAO) levels and heart failure (HF) outcomes. METHODS AND

resultsTrimethylamine N-oxide levels were measured in two cohorts with acute HF at two sites. The UK Leicester cohort consisted mainly of Caucasian (n = 842, 77%) and South Asian (n = 129, 12%) patients, whereas patients in the Japanese cohort (n = 116, 11%) were all Japanese. The primary endpoint was the measurement of all-cause mortality and/or HF rehospitalization within 1 year post-admission. Association of TMAO levels with outcome was compared in the entire population and between ethnic groups after adjustment for clinical parameters. TMAO levels were significantly higher in Japanese patients [median (interquartile range): 9.9 μM (5.2-22.8)] than in Caucasian [5.9 μM (3.6-10.8)] and South Asian [4.5 μM (3.1-8.4)] (P < 0.001) patients. There were no differences in the rate of mortality and/or HF rehospitalization between the ethnic groups (P = 0.096). Overall, higher TMAO levels showed associations with mortality and/or rehospitalization after adjustment for confounders ( P = 0.002). Despite no differences between ethnicity and association with mortality/HF after adjustment (P = 0.311), only in Caucasian patients were TMAO levels able to stratify for a mortality/HF event (P < 0.001).

conclusionsDifferences were observed in the association of mortality and/or rehospitalization based on circulating TMAO levels. Elevated TMAO levels in Caucasian patients showed increased association with adverse outcomes, but not in non-Caucasian patients.

Indexed as

Heart FailureMethylaminesCohort StudiesHumansMethylaminestrimethyloxamineEthnicityGut metaboliteHeart failureOutcomesTMAO

Identifiers

PMID32598563
PMCPMC7524106
OpenAlexW3038432612

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.