ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021
Comparing Biological Age Estimates Using Domain-Specific Measures From the Canadian Longitudinal Study on Aging.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
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- Longitudinal digital phenotyping of activity rhythms and biological aging using commercial wearables.Nature communications · 2026Article
- Molecular markers, mechanisms and metrics of biological aging: a scoping review.Frontiers in aging · 2026Review
- Association of biological age acceleration with mortality in adults with diabetes or prediabetes: a mediating role of physical activity.Aging clinical and experimental research · 2025Article
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- Progress in the study of aging marker criteria in human populations.Frontiers in public health · 2024Review
- Associations of Early-Life Adversity With Later-Life Epigenetic Aging Profiles in the Multi-Ethnic Study of Atherosclerosis.American journal of epidemiology · 2023Article
- Discordant Biological and Chronological Age: Implications for Cognitive Decline and Frailty.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- All-Subset Analysis Improves the Predictive Accuracy of Biological Age for All-Cause Mortality in Chinese and U.S. Populations.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- In utero exposure to the Great Depression is reflected in late-life epigenetic aging signatures.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons.Immunity & ageing : I & A · 2022Article
- Does Modulation of an Epigenetic Clock Define a Geroprotector?Advances in geriatric medicine and research · 2022Article
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- Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy.Nature aging · 2021Article
- Frailty Status Among the Elderly of Different Genders and the Death Risk: A Follow-Up Study.Frontiers in medicine · 2021Article
- Comparative Dynamics of Individual Ageing among the Investigative Type of Professionals Living in Russia and Russian Migrants to the EU Countries.European journal of investigation in health, psychology and education · 2020Article
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Authors and funding
6 authors.
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Abstract
Many studies have shown that estimates of biological age (BA) can predict health-related outcomes in older adults. Often, researchers employ multiple measures belonging to a variety of biological/physiological systems, and assess the validity of BA estimates by how well they approximate chronological age (CA). However, it is not clear whether this is the best approach for judging a BA estimate, or whether certain groups of measures are more informative to this end. Using data from the Canadian Longitudinal Study on Aging, we composed panels of biological measures based on the physiological systems/domains they belong to (blood, organ function, physical/cognitive performance), and also composed a panel of measures that optimized the association of BA with CA. We then compared BA estimates for each according to their association with CA and health-related outcomes, including frailty, multimorbidity, chronic condition domains, disability, and health care utilization. Although BA estimated using all 40 measures (r = 0.74) or our age-optimized panel (r = 0.77) most closely approximated CA, the strength of associations to health-related outcomes was comparable or weaker than that of our panel composed only of physical performance measures (CA r = 0.59). All BA estimates were significantly associated to the outcomes considered, with exception to the neurological and musculoskeletal disease domains, and only varied slightly by sex. In summary, while the approximation of CA is important to consider when estimating BA, the strength of associations to prospective outcomes may be of greater importance. Hence, the context in which BA is estimated should be influenced by an investigator's specific research goals.
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