Evidence map›Paper›PMID 32598376›Full record

ArticlePloS one2020

Undefeated-Changing the phenamacril scaffold is not enough to beat resistant Fusarium.

Rasmus D Wollenberg, Søren S Donau, Manuel H Taft, Zoltan Balázs, Sven Giese, Claudia Thiel, Jens L Sørensen, Thorbjørn T Nielsen, Henriette Giese, Dietmar J Manstein and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rasmus D WollenbergDepartment of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark.
Søren S DonauDepartment of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark.
Manuel H TaftInstitute for Biophysical Chemistry, OE4350, Hannover Medical School, Hannover, Germany.ORCID 0000-0001-5853-8629
Zoltan BalázsDepartment of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark.
Sven GieseInstitute for Biophysical Chemistry, OE4350, Hannover Medical School, Hannover, Germany.
Claudia ThielInstitute for Biophysical Chemistry, OE4350, Hannover Medical School, Hannover, Germany.
Jens L SørensenDepartment of Chemistry and Bioscience, Aalborg University, Esbjerg, Denmark.
Thorbjørn T NielsenDepartment of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark.
Henriette GieseDepartment of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark.
Dietmar J MansteinInstitute for Biophysical Chemistry, OE4350, Hannover Medical School, Hannover, Germany.
Reinhard WimmerDepartment of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark.
Teis E SondergaardDepartment of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark.ORCID 0000-0002-4455-7498

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Filamentous fungi belonging to the genus Fusarium are notorious plant-pathogens that infect, damage and contaminate a wide variety of important crops. Phenamacril is the first member of a novel class of single-site acting cyanoacrylate fungicides which has proven highly effective against important members of the genus Fusarium. However, the recent emergence of field-resistant strains exhibiting qualitative resistance poses a major obstacle for the continued use of phenamacril. In this study, we synthesized novel cyanoacrylate compounds based on the phenamacril-scaffold to test their growth-inhibitory potential against wild-type Fusarium and phenamacril-resistant strains. Our findings show that most chemical modifications to the phenamacril-scaffold are associated with almost complete loss of fungicidal activity and in vitro inhibition of myosin motor domain ATPase activity.

Indexed as

CyanoacrylatesDrug Resistance, FungalFungicides, IndustrialFusariumCyanoacrylatesFungicides, Industrialphenamacril

Identifiers

PMID32598376
PMCPMC7323951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.