Evidence map›Paper›PMID 32598214›Full record

ArticleMolecular imaging

Evaluation of Musculoskeletal and Pulmonary Bacterial Infections With [

Steve Y Cho, Steven P Rowe, Sanjay K Jain, Lew C Schon, Rex C Yung, Tariq A Nayfeh, Clifton O Bingham, Catherine A Foss, Sridhar Nimmagadda, Martin G Pomper

Open access · goldAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Artificial Intelligence and Infectious Disease Imaging.The Journal of infectious diseases · 2023
    Article
  4. Article
  5. Radiometal chelators for infection diagnostics.Frontiers in nuclear medicine · 2023
    Article
  6. Infection-specific PET imaging withFrontiers in microbiology · 2023
    Article
  7. Review
  8. Review
  9. Pathophysiology and Molecular Imaging of Diabetic Foot Infections.International journal of molecular sciences · 2021
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Steve Y ChoThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Steven P RoweThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-2897-4694
Sanjay K JainDivision of Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lew C SchonDepartment of Orthopedic Surgery, MedStar Union Memorial Hospital, Baltimore, MD, USA.
Rex C YungDivision of Pulmonary Medicine and Critical Care, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Tariq A NayfehMetro Orthopedics and Sports Therapy, Potomac, MD, USA.
Clifton O BinghamDivision of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Catherine A FossThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sridhar NimmagaddaThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-6413-7191
Martin G PomperThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USUniversity of Wisconsin–Madison · US

Funding

Sample Processing and Immunoassay Research CoreP30AR070254 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI CLIFTON O BINGHAM, Antony Rosen · 2016 to 2026
$8.9M
Phenotype-Specific Immune Responses in the Systemic VasculitidesP30AR053503 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ROSEN, ANTONY · 2006 to 2015
$6.4M
TK-based Infection ImagingR01EB009367 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI POMPER, MARTIN G · 2010 to 2013
$2.1M
NIAMS NIH HHS P30 AR053503NIAMS NIH HHS P30 AR070254NIBIB NIH HHS R01 EB009367
6 · The paper itself

Abstract

purposeImaging is limited in the evaluation of bacterial infection. Direct imaging of in situ bacteria holds promise for noninvasive diagnosis. We investigated the ability of a bacterial thymidine kinase inhibitor ([

methodsThirty-three patients were prospectively accrued: 16 with suspected musculoskeletal infection, 14 with suspected pulmonary infection, and 3 with known rheumatoid arthritis without infection. Thirty-one patients were imaged with [

resultsSensitivity, specificity, positive-predictive value, negative-predictive value, and accuracy of [

conclusionsThe high number of patients with equivocal clinical findings prevented definitive conclusions from being made regarding the diagnostic efficacy of [

Indexed as

Positron Emission Tomography Computed TomographyAdultAgedAged, 80 and overArabinofuranosyluracilBacterial InfectionsFemaleFluorodeoxyglucose F18HumansIodine RadioisotopesMaleMiddle AgedMusculoskeletal DiseasesPredictive Value of TestsRespiratory Tract InfectionsSensitivity and SpecificityArabinofuranosyluracilfialuridineFluorodeoxyglucose F18Iodine-124Iodine Radioisotopesinfectionmolecular imagingPETthymidine kinase

Identifiers

PMID32598214
PMCPMC7325456
OpenAlexW3037671836

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.