Evidence map›Paper›PMID 32597982›Full record

ArticleEuropean heart journal. Cardiovascular pharmacotherapy2021

Adherence to prescribed medications in patients with heart failure: insights from liquid chromatography-tandem mass spectrometry-based urine analysis.

Joanne Simpson, Colette E Jackson, Caroline Haig, Pardeep S Jhund, Maciej Tomaszewski, Roy S Gardner, Yannis Tsorlalis, Mark C Petrie, John J V McMurray, Iain B Squire and 1 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Cardiovascular pharmacotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06035978 (Use of Determination of Drug Levels to Optimize Pharmacotherapy of Heart Failure), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06035978 phase4unknown statusnot on this mapstarted 2024, after this paper: background citation

Use of Determination of Drug Levels to Optimize Pharmacotherapy of Heart Failure

TypeinterventionalSponsorUniversity Hospital OstravaRan2024 to 2026Enrolled100ConditionsCardiovascular Diseases, Heart Failure With Reduced Ejection FractionArmsNebivolol, Valsartan and Sacubitril, Carvedilol, Bisoprolol, Metoprolol
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Joanne SimpsonInstitute of Cardiovascular and Medical Sciences, University of Glasgow, British Heart Foundation Glasgow Cardiovascular Research Centre, 126 University Place, Glasgow G12 8TA, UK.
Colette E JacksonInstitute of Cardiovascular and Medical Sciences, University of Glasgow, British Heart Foundation Glasgow Cardiovascular Research Centre, 126 University Place, Glasgow G12 8TA, UK.
Caroline HaigRobertson Centre for Biostatistics, Boyd Orr Building, University of Glasgow, Glasgow G12 8QQ, UK.
Pardeep S JhundInstitute of Cardiovascular and Medical Sciences, University of Glasgow, British Heart Foundation Glasgow Cardiovascular Research Centre, 126 University Place, Glasgow G12 8TA, UK.ORCID 0000-0003-4306-5317
Maciej TomaszewskiDivision of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Upper Brook Street, Manchester M13 9PT, UK.ORCID 0000-0001-8215-6567
Roy S GardnerInstitute of Cardiovascular and Medical Sciences, University of Glasgow, British Heart Foundation Glasgow Cardiovascular Research Centre, 126 University Place, Glasgow G12 8TA, UK.
Yannis TsorlalisInstitute of Cardiovascular and Medical Sciences, University of Glasgow, British Heart Foundation Glasgow Cardiovascular Research Centre, 126 University Place, Glasgow G12 8TA, UK.
Mark C PetrieInstitute of Cardiovascular and Medical Sciences, University of Glasgow, British Heart Foundation Glasgow Cardiovascular Research Centre, 126 University Place, Glasgow G12 8TA, UK.ORCID 0000-0002-6333-9496
John J V McMurrayInstitute of Cardiovascular and Medical Sciences, University of Glasgow, British Heart Foundation Glasgow Cardiovascular Research Centre, 126 University Place, Glasgow G12 8TA, UK.
Iain B SquireDepartment of Cardiovascular Sciences, University of Leicester, NIHR Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.
Pankaj GuptaDepartment of Cardiovascular Sciences, University of Leicester, NIHR Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.
British Heart Foundation · GBUniversity of Leicester · GBManchester Academic Health Science Centre · GBUniversity of Glasgow · GB

Funding

British Heart Foundation CS/17/3/32799
6 · The paper itself

Abstract

aimsNone of the existing studies on adherence have directly measured levels of all medications (or their metabolites) in patients with heart failure (HF). METHODS AND

resultsWe used liquid chromatography-tandem mass spectrometry to measure the presence of prescribed drugs (diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, and mineralocorticoid receptor antagonists) in the urine of patients reviewed 4-6 weeks after hospitalization with HF. Patients were unaware that adherence was being assessed. Of the 341 patients studied, 281 (82.4%) were adherent, i.e. had all prescribed drugs of interest detectable in their urine. Conversely, 60 patients (17.6%) were partially or completely non-adherent. Notably, 24 of the 60 were non-adherent to only diuretic therapy and only seven out of all 341 patients studied (2.1%) were completely non-adherent to all prescribed HF drugs. There were no major differences in baseline characteristics between adherent and non-adherent patients.

conclusionNon-adherence, assessed using a single spot urine measurement of drug levels, was confirmed in one of five patients evaluated 4-6 weeks after hospitalization with HF.

Indexed as

Heart FailureTandem Mass SpectrometryAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsChromatography, LiquidHumansAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsAdherenceHeart failureMass spectrometryUrine

Identifiers

PMID32597982
PMCPMC8302254
OpenAlexW3037817914

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.