ArticleThe Journal of infectious diseases2021
Cardiac Microlesions Form During Severe Bacteremic Enterococcus faecalis Infection.
Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Laboratory and Microbiological Considerations in Sepsis-Induced Cardiac Dysfunction.Medicina (Kaunas, Lithuania) · 2025Article
- Pathogenic bacteria enriched in the oral microbiota might be associated with recurrent pulmonary infections in elderly individuals.Aging clinical and experimental research · 2025Article
- Membrane Lipids Augment Cell Envelope Stress Signaling via the MadRS System to Defend Against Antimicrobial Peptides and Antibiotics in Enterococcus faecalis.The Journal of infectious diseases · 2025Article
- Perioperative Multi-Kingdom Gut Microbiota Alters in Coronary Artery Bypass Grafting.Biomedicines · 2025Article
- Transcription modulation of pathogenic streptococcal and enterococcal species using CRISPRi technology.PLoS pathogens · 2024Review
- The prostaglandin D2 antagonist asapiprant ameliorates clinical severity in young hosts infected with invasiveInfection and immunity · 2024Article
- Enterococcus faecalis: implications for host health.World journal of microbiology & biotechnology · 2024Review
- Exploration of the Antibacterial and Anti-Inflammatory Activity of a Novel Antimicrobial Peptide Brevinin-1BW.Molecules (Basel, Switzerland) · 2024Article
- Current Knowledge of Enterococcal Endocarditis: A Disease Lurking in Plain Sight of Health Providers.Pathogens (Basel, Switzerland) · 2024Review
- Necroptosis in bacterial infections.Frontiers in immunology · 2024Review
- Enterococcal-host interactions in the gastrointestinal tract and beyond.FEMS microbes · 2024Review
- Membrane Lipids Augment Cell Envelope Stress Signaling and Resistance to Antibiotics and Antimicrobial Peptides inbioRxiv : the preprint server for biology · 2023Article
- Article
- Enterococcal Endocarditis: Hiding in Plain Sight.Frontiers in cellular and infection microbiology · 2021Review
- Article
- The pathogenesis of cardiac microlesion formation during severe bacteremic infection.PLoS pathogens · 2020Review
- Comparative efficacy of hospital disinfectants against nosocomial infection pathogens.Antimicrobial resistance and infection control · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Enterococcus faecalis is a significant cause of hospital-acquired bacteremia. Herein, the discovery is reported that cardiac microlesions form during severe bacteremic E. faecalis infection in mice. The cardiac microlesions were identical in appearance to those formed by Streptococcus pneumoniae during invasive pneumococcal disease. However, E. faecalis does not encode the virulence determinants implicated in pneumococcal microlesion formation. Rather, disulfide bond forming protein A (DsbA) was found to be required for E. faecalis virulence in a Caenorhabditis elegans model and was necessary for efficient cardiac microlesion formation. Furthermore, E. faecalis promoted cardiomyocyte apoptotic and necroptotic cell death at sites of microlesion formation. Additionally, loss of DsbA caused an increase in proinflammatory cytokines, unlike the wild-type strain, which suppressed the immune response. In conclusion, we establish that E. faecalis is capable of forming cardiac microlesions and identify features of both the bacterium and the host response that are mechanistically involved.
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Registered trials
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