Evidence map›Paper›PMID 32597752›Full record

ArticleeLife2020

Aromatic interactions with membrane modulate human BK channel activation.

Mahdieh Yazdani, Guohui Zhang, Zhiguang Jia, Jingyi Shi, Jianmin Cui, Jianhan Chen

Abstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mahdieh Yazdani *Department of Chemistry, University of Massachusetts, Amherst, United States.ORCID https://orcid.org/0000-0003-1300-4599
Guohui Zhang *Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St Louis, United States.ORCID https://orcid.org/0000-0001-6905-0637
Zhiguang Jia *Department of Chemistry, University of Massachusetts, Amherst, United States.
Jingyi ShiDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St Louis, United States.
Jianmin CuiDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St Louis, United States.ORCID https://orcid.org/0000-0002-9198-6332
Jianhan ChenDepartment of Chemistry, University of Massachusetts, Amherst, United States.ORCID https://orcid.org/0000-0002-5281-1150

Funding

Mechanism of BK Channel GatingR01HL142301 · NHLBI · WASHINGTON UNIVERSITY · PI SILVA, JONATHAN R · 2018 to 2021
$2.9M
Multi-scale enhanced sampling of disordered proteins: Admin Supplement InstrumentationR01GM114300 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI CHEN, JIANHAN · 2016 to 2020
$1.5M
NHLBI NIH HHS R01 HL142301NIGMS NIH HHS R01 GM114300
6 · The paper itself

Abstract

Large-conductance potassium (BK) channels are transmembrane (TM) proteins that can be synergistically and independently activated by membrane voltage and intracellular Ca

Indexed as

AnimalsCalciumCell MembraneElectrophysiological PhenomenaHumansLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLarge-Conductance Calcium-Activated Potassium ChannelsProtein Structure, TertiaryXenopus laevisCalciumKCNMA1 protein, humanLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLarge-Conductance Calcium-Activated Potassium Channelsallosteric couplingatomistic simulationchannel gatinghydrophobic dewettingmembrane anchoringmolecular biophysicsstructural biologyxenopus

Identifiers

PMID32597752
PMCPMC7371421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.