Evidence map›Paper›PMID 32597552›Full record

ArticleCell proliferation2020

High-efficient generation of VCAM-1

Yimeng Wei, Leisheng Zhang, Ying Chi, Xiang Ren, Yuchen Gao, Baoquan Song, Chengwen Li, Zhibo Han, Lei Zhang, Zhongchao Han

Abstract read
In one paragraph

Article in Cell proliferation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. VCAM-1Neurochemical research · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Improved therapeutic consistency and efficacy of CD317Stem cell research & therapy · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. VCAM-1Neurochemical research · 2023
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yimeng WeiState Key Laboratory of Experimental Hematology & National Clinical Research Center for Blood Disease, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Leisheng ZhangState Key Laboratory of Experimental Hematology & National Clinical Research Center for Blood Disease, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.ORCID https://orcid.org/0000-0001-6540-0943
Ying ChiState Key Laboratory of Experimental Hematology & National Clinical Research Center for Blood Disease, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Xiang RenState Key Laboratory of Experimental Hematology & National Clinical Research Center for Blood Disease, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Yuchen GaoState Key Laboratory of Experimental Hematology & National Clinical Research Center for Blood Disease, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Baoquan SongJiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Chengwen LiState Key Laboratory of Experimental Hematology & National Clinical Research Center for Blood Disease, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Zhibo HanState Key Laboratory of Experimental Hematology & National Clinical Research Center for Blood Disease, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Lei ZhangState Key Laboratory of Experimental Hematology & National Clinical Research Center for Blood Disease, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Zhongchao HanState Key Laboratory of Experimental Hematology & National Clinical Research Center for Blood Disease, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

Funding

CAMS Innovation Fund for Medical Sciences 2016-I2M-1-017CAMS Key Laboratory of Gene Therapy for Blood Diseases 2017PT31047CAMS Key Laboratory of Gene Therapy for Blood Diseases 2018PT31038CAMS Key Laboratory of Gene Therapy for Blood Diseases 2018PT32028China Postdoctoral Science Foundation 2019M661033China Postdoctoral Science Foundation JCQY012Emergency project funded by Department of Science and Technology of Jiangxi ProvinceKey project funded by Department of Science and Technology of Shangrao CityNanyang Science and Technology Project of He-nan Province JCQY012National Natural Science Foundation of China 81330015 81700119 81900126Natural Science Foundation of Tianjin 19JCQNJC12500Natural Science Foundation of Tianjin City 19JCQNJC12500Project funded by China Postdoctoral Science Foundation 2019M661033Science and Technology Project of Tianjin 17ZXSCSY00030The Beijing-Tianjin-Hebei Basic Research Project 18JCZDJC44600The Beijing-Tianjin-Hebei Basic Research Project H2018206423
6 · The paper itself

Abstract

objectiveLongitudinal studies have indicated VCAM-1 MATERIALS AND

methodsWe primarily took advantage of a cytokine-based programming strategy for large-scale VCAM-1

resultsIII-MSCs with high-proportioned VCAM-1 expression were obtained by combining IL-1β, IL-4 with IFN-γ, which exhibited comparable immunophenotype with untreated hUC-MSCs (NT-MSCs) but revealed multidimensional superiorities both at the cellular and molecular levels. Simultaneously, systemic infusion of III-MSCs could significantly ameliorate clinicopathological features and finally help facilitate haematopoietic reconstruction and immunoregulation in AA mice.

conclusionsWe have established a high-efficient procedure for large-scale generation of III-MSCs with preferable signatures and efficacy upon aplastic anaemia in mice. Our findings suggested that III-MSCs were advantageous sources with multifaceted characteristics for regenerative medicine.

Indexed as

Anemia, AplasticAnimalsCell DifferentiationCell ProliferationCells, CulturedImmunophenotypingMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMiceUmbilical CordVascular Cell Adhesion Molecule-1Vascular Cell Adhesion Molecule-1Aplastic anaemiagenetic alterationhUC-MSCsimmunoregulationproangiogenesisVCAM-1

Identifiers

PMID32597552
PMCPMC7445411

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.