Evidence map›Paper›PMID 32597024›Full record

ArticleESC heart failure2020

Prolonged suppression of the anti-oxidant/anti-inflammatory effects of BNP post-Takotsubo syndrome.

Saifei Liu, Doan Ngo, Yuliy Chirkov, Jeanette Stansborough, Cher-Rin Chong, John D Horowitz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The role of inflammation in takotsubo syndrome: A new therapeutic target?Journal of cellular and molecular medicine · 2024
    Review
  2. The Immunology of Takotsubo Syndrome.Frontiers in immunology · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Saifei LiuDepartment of Cardiology and Clinical Pharmacology, Basil Hetzel Institute, The Queen Elizabeth Hospital, The University of Adelaide, 28 Woodville Road, Woodville South, South Australia, 5011, Australia.
Doan NgoDepartment of Cardiology and Clinical Pharmacology, Basil Hetzel Institute, The Queen Elizabeth Hospital, The University of Adelaide, 28 Woodville Road, Woodville South, South Australia, 5011, Australia.
Yuliy ChirkovDepartment of Cardiology and Clinical Pharmacology, Basil Hetzel Institute, The Queen Elizabeth Hospital, The University of Adelaide, 28 Woodville Road, Woodville South, South Australia, 5011, Australia.
Jeanette StansboroughDepartment of Cardiology, The Queen Elizabeth Hospital, South Australia, Australia.
Cher-Rin ChongDepartment of Cardiology and Clinical Pharmacology, Basil Hetzel Institute, The Queen Elizabeth Hospital, The University of Adelaide, 28 Woodville Road, Woodville South, South Australia, 5011, Australia.
John D HorowitzDepartment of Cardiology and Clinical Pharmacology, Basil Hetzel Institute, The Queen Elizabeth Hospital, The University of Adelaide, 28 Woodville Road, Woodville South, South Australia, 5011, Australia.

Funding

National Health and Medical Research CouncilNational Health and Medical Research Council (NHMRC)
6 · The paper itself

Abstract

aimsTakotsubo syndrome (TTS) episodes are primarily initiated by 'pulse' release of catecholamines inducing neutrophil infiltration and myocardial inflammation in susceptible individuals (largely ageing women). Evidence of myocardial inflammation and associated energetic impairment persists for ≥ 3 months post-acute TTS episodes, suggesting the existence of additional 'perpetuating' mechanisms. The effects of B-type natriuretic peptide (BNP) in suppressing superoxide (O METHODS AND

resultsTTS patients were studied acutely (n = 34) and 3 months thereafter (n = 13) and compared with control subjects (n = 25). O

conclusions(1) While TTS is associated with marked and prolonged release of BNP, there is virtually total loss of the ability of BNP to suppress neutrophil O

Indexed as

Natriuretic Peptide, BrainTakotsubo CardiomyopathyAnti-Inflammatory AgentsAntioxidantsFemaleHumansN-Formylmethionine Leucyl-PhenylalanineAnti-Inflammatory AgentsAntioxidantsNatriuretic Peptide, BrainN-Formylmethionine Leucyl-PhenylalanineBNPNeutrophilsSuperoxideTakotsubo syndrome

Identifiers

PMID32597024
PMCPMC7524045

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.