Evidence map›Paper›PMID 32597007›Full record

ArticlePhysiological reports2020

CD44 impacts glomerular parietal epithelial cell changes in the aged mouse kidney.

Hiroko Hamatani, Diana G Eng, Keiju Hiromura, Jeffrey W Pippin, Stuart J Shankland

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Hiroko HamataniDivision of Nephrology, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0001-7727-6986
Diana G EngDivision of Nephrology, University of Washington School of Medicine, Seattle, WA, USA.
Keiju HiromuraDepartment of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Jeffrey W PippinDivision of Nephrology, University of Washington School of Medicine, Seattle, WA, USA.
Stuart J ShanklandDivision of Nephrology, University of Washington School of Medicine, Seattle, WA, USA.
University of Washington · USGunma University · JP

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
Juxta-glomerular cells serve as glomerular epithelial cell progenitors in glomerular diseaseR01DK097598 · NIDDK · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES, WESSELY, OLIVER · 2014 to 2022
$5.2M
Reduced Glomerular Progenitors Impair Regeneration in Aged KidneyR01AG046231 · NIA · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES · 2016 to 2020
$2.6M
Kidney Aging Impairs Progenitor and Endocrine FunctionR01DK123031 · NIDDK · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES · 2020 to 2023
$2.5M
NIA NIH HHS 5R01AG046231-04NIA NIH HHS R01 AG046231NIDDK NIH HHS 2R01DK097598-06NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK097598NIDDK NIH HHS R01 DK123031
6 · The paper itself

Abstract

CD44 contributes to the activation of glomerular parietal epithelial cells (PECs). Although CD44 expression is higher in PECs of healthy aged mice, the biological role of CD44 in PECs in this context remains unclear. Accordingly, young (4 months) and aged (24 months) CD44

Indexed as

Age FactorsAnimalsDisease Models, AnimalEpithelial CellsFemaleHyaluronan ReceptorsKidney DiseasesKidney GlomerulusMaleMiceMice, KnockoutMitogen-Activated Protein Kinase 3PhosphorylationPodocytesTOR Serine-Threonine KinasesCd44 protein, mouseHyaluronan ReceptorsMapk3 protein, mouseMitogen-Activated Protein Kinase 3mTOR protein, mouseTOR Serine-Threonine KinasesBowman's capsulecorticalmedullarymTORpERKpodocyte

Identifiers

PMID32597007
PMCPMC7322268
OpenAlexW3037792388

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.