SynthesisPediatric nephrology (Berlin, Germany)2021
Pre-pregnancy obesity and risk of congenital abnormalities of the kidney and urinary tract (CAKUT)-systematic review, meta-analysis and ecological study.
Synthesis in Pediatric nephrology (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Maternal adiposity and perinatal and offspring outcomes: an umbrella review.Nature human behaviour · 2024Pooled it
- Follow-up of congenital abnormalities of the kidney and urinary tract from the antenatal period to the first year of life: a retrospective study from Turkey.Childhood kidney diseases · 2025Article
- Clinical features of overt versus diagnosed pre-existing diabetes in pregnancy.Journal of diabetes investigation · 2025Article
- Translational strategies to uncover the etiology of congenital anomalies of the kidney and urinary tract.Pediatric nephrology (Berlin, Germany) · 2025Review
- Maternal pre-pregnancy overweight or obesity and risk of birth defects in offspring: Population-based cohort study.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Prevalence, characteristics and risk factors of birth defects in central China livebirths, 2015-2022.Frontiers in public health · 2024Article
- Risk factors of congenital anomalies of the kidney and urinary tract (CAKUT): Exposure to mobile phones during pregnancy.Turkish journal of medical sciences · 2024Article
- Environmental and parental risk factors for congenital solitary functioning kidney - a case-control study.Pediatric nephrology (Berlin, Germany) · 2023Article
- Effect of a 60-day weight reduction intervention prior to IVF/ICSI on perinatal outcomes in overweight or obese infertile women.Frontiers in endocrinology · 2022Article
- Overlap of vitamin A and vitamin D target genes with CAKUT-related processes.F1000Research · 2021Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is increasing evidence that maternal obesity is associated with several structural birth defects. Congenital abnormalities of the kidney and urinary tract (CAKUT) account for 30 to 50% of children starting kidney replacement therapy (KRT). We conducted a systematic review, meta-analysis and ecological study to explore the relationship between maternal obesity and CAKUT.
methodsA systematic literature search was conducted in EMBASE, MEDLINE, Global Health, The Cochrane Library, Scopus and Web of Science. Study quality was assessed for bias and confounding. A meta-analysis using a random effect model was carried out to obtain a summary odds ratio (OR) and 95% confidence interval (CI). In the ecological study, country-level data were used to examine the correlation of secular trends in female obesity, CAKUT incidence and incidence of KRT.
resultsEight epidemiological studies were included in the review-4 cohort studies and 4 case-control studies-7 of which were included in the meta-analysis. There was evidence of a positive association between obesity during pregnancy and the risk of CAKUT, with a summary OR = 1.14 (1.02-1.27). No association was seen with overweight, nor a dose response with increasing obesity. There was an increasing trend in countries' proportion of female obesity and an increasing trend in reported CAKUT incidence with specific rises seen in congenital hydronephrosis (CH) and multicystic kidney dysplasia (MCKD).
conclusionsOur findings suggest that pre-pregnancy obesity may be associated with increased risk of CAKUT at population level. Graphical abstract.
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