ArticleJournal of materials chemistry. B2020
Electrostatic interactions regulate the release of small molecules from supramolecular hydrogels.
Article in Journal of materials chemistry. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Non-Systemic Oral Cellulose-Based Superabsorbent Hydrogels for Weight Management: Potential Drug-Device Interactions Estimated by a Simplified In Vitro Assay.Pharmaceutics · 2026Article
- Leveraging Dynamic Electrostatic and Hydrophobic Interactions for Biomedical Hydrogels.ACS macro letters · 2026Review
- Bio-Polymers Based Functionalized Hydrogel Carriers for Targeted Oncology Therapies: Current Progress and Future Perspectives.International journal of nanomedicine · 2026Review
- Self-Assembly Properties of Xylene-Derived Constitutional Isomers of Fmoc-Phenylalanine.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Self-Assembly Pathway Influence on Dehydropeptide-Based Gel Properties and Drug Release.Macromolecular bioscience · 2025Article
- Simple pH-Triggered Control over Hydrogel Formation by Acetyl Valine.Molecules (Basel, Switzerland) · 2025Article
- A Peptide Hydrogel Responsive to Reactive Oxygen Species and pH for the Protection and Sustained Delivery of Insulin-like Growth Factor 1 in Osteoarthritis Treatment.ACS applied bio materials · 2025Article
- Supramolecular hydrogel actuators with reprogrammable magnetic orientation by locally mediated viscoelasticity and pinning force.Science advances · 2025Article
- New Supramolecular Hydrogels Based on Diastereomeric Dehydrotripeptide Mixtures for Potential Drug Delivery Applications.Gels (Basel, Switzerland) · 2024Article
- Hydrogel-Based Therapy for Age-Related Macular Degeneration: Current Innovations, Impediments, and Future Perspectives.Gels (Basel, Switzerland) · 2024Review
- Electrostatic Loading and Photoredox-Accelerated Release of Antibiotics from Oligoviologen-Crosslinked Hydrogels Using Red Light.Materials today. Chemistry · 2024Article
- Hydrogel drug delivery systems for minimally invasive local immunotherapy of cancer.Advanced drug delivery reviews · 2023Review
- Rosacea Topical Treatment and Care: From Traditional to New Drug Delivery Systems.Molecular pharmaceutics · 2023Review
- Versatile Potential of Photo-Cross-Linkable Silk Fibroin: Roadmap from Chemical Processing Toward Regenerative Medicine and Biofabrication Applications.Biomacromolecules · 2023Review
- Supramolecular Phenylalanine-Derived Hydrogels for the Sustained Release of Functional Proteins.ACS biomaterials science & engineering · 2023Article
- Anion Effects on the Supramolecular Self-Assembly of Cationic Phenylalanine Derivatives.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Aryl-Capped Lysine-Dehydroamino Acid Dipeptide Supergelators as Potential Drug Release Systems.International journal of molecular sciences · 2022Article
- Applications of capillary action in drug delivery.iScience · 2021Review
- Bolaamphiphilic Bis-Dehydropeptide Hydrogels as Potential Drug Release Systems.Gels (Basel, Switzerland) · 2021Article
- Evaluation of a Model Photo-Caged Dehydropeptide as a Stimuli-Responsive Supramolecular Hydrogel.Nanomaterials (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Supramolecular hydrogels have great potential as biomaterials for sustained delivery of therapeutics. While peptide-based supramolecular hydrogels have been developed that show promise for drug delivery applications, the high cost of production has limited their widespread adoption. Low molecular weight (LMW) supramolecular hydrogels are emerging as attractive and inexpensive alternatives to peptide-based hydrogels. We recently reported novel cationic fluorenylmethyloxycarbonyl-modified phenylalanine (Fmoc-Phe) hydrogels for localized and sustained in vivo release of an anti-inflammatory agent for functional pain remediation. In an effort to further elucidate design principles to optimize these materials for delivery of a variety of molecular agents, we herein report a systematic examination of electrostatic effects on the release of cargo molecules from Fmoc-Phe derived hydrogels. Specifically, we interrogate the release of cationic, anionic, and neutral cargo molecules from a series of cationic and anionic Fmoc-Phe derived hydrogels. We observed that cargo was readily released from the hydrogels except when the cargo and hydrogel network had complementary charges, in which case the cargo was highly retained in the network. These results demonstrate that the electrostatic characteristics of both the hydrogel network and the specific cargo are critical design parameters in the formulation of LMW supramolecular hydrogel systems in the development of next-generation materials for drug delivery applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.