ReviewInternational journal of bioprinting2019
Additive manufacturing of bone scaffolds.
Review in International journal of bioprinting, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed.
- 3D-Printed PLA/HA Composite Scaffolds: Balancing Mechanical Properties for Bone Tissue Engineering.Materials (Basel, Switzerland) · 2026Article
- Bone Grafts: Everything You Need to Know.Journal of periodontal research · 2026Review
- Investigation on Mechanical Properties of Functional Graded Hybrid TPMS Structures Inspired Bone Scaffolds.Polymers · 2026Article
- Bone regenerative efficacy of binder-jet fabricated hydroxyapatite granules with and without biomimetic octacalcium phosphate-coated modification in a rat critical-sized calvarial defect model.Regenerative biomaterials · 2026Article
- Advances in Titanium-Based Biomaterial for Human Bone Scaffolds: Narrative Review on Design, Fabrication, Surface Engineering, Implantation, and Biological Evaluation.Materials (Basel, Switzerland) · 2025Review
- Melt-Extrusion Additive Manufacturing for Tissue Engineering: Applications and Limitations.3D printing and additive manufacturing · 2025Article
- Advancing Scaffold Architecture for Bone Tissue Engineering: A Comparative Study of 3D-Printed β-TCP Constructs in Dynamic Culture with pBMSC.Journal of functional biomaterials · 2025Article
- Advances in 3D-printed scaffold technologies for bone defect repair: materials, biomechanics, and clinical prospects.Biomedical engineering online · 2025Review
- Article
- Integrating Micro- and Nanostructured Platforms and Biological Drugs to Enhance Biomaterial-Based Bone Regeneration Strategies.Biomacromolecules · 2025Review
- Polycaprolactone for Hard Tissue Regeneration: Scaffold Design and In Vivo Implications.Bioengineering (Basel, Switzerland) · 2025Review
- From "immune silence" to "immune dialogue": modification strategies for bone substitutes based on bone immunomodulatory characteristics.Frontiers in cell and developmental biology · 2025Review
- Article
- On the Fused Deposition Modelling of Personalised Bio-Scaffolds: Materials, Design, and Manufacturing Aspects.Bioengineering (Basel, Switzerland) · 2024Review
- Fabrication Strategies for Bioceramic Scaffolds in Bone Tissue Engineering with Generative Design Applications.Biomimetics (Basel, Switzerland) · 2024Review
- Optimizing Filament-Based TCP Scaffold Design for Osteoconduction and Bone Augmentation: Insights from In Vivo Rabbit Models.Journal of functional biomaterials · 2024Article
- Forged to heal: The role of metallic cellular solids in bone tissue engineering.Materials today. Bio · 2023Article
- Efficacy of bone defect therapy involving various surface treatments of titanium alloy implants: an in vivo and in vitro study.Scientific reports · 2023Article
- A Comprehensive Mechanical Characterization of Subject-Specific 3D Printed Scaffolds Mimicking Trabecular Bone Architecture Biomechanics.Life (Basel, Switzerland) · 2023Article
- 3D printing metal implants in orthopedic surgery: Methods, applications and future prospects.Journal of orthopaedic translation · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Additive manufacturing (AM) can obtain not only customized external shape but also porous internal structure for scaffolds, both of which are of great importance for repairing large segmental bone defects. The scaffold fabrication process generally involves scaffold design, AM, and post-treatments. Thus, this article firstly reviews the state-of-the-art of scaffold design, including computer-aided design, reverse modeling, topology optimization, and mathematical modeling. In addition, the current characteristics of several typical AM techniques, including selective laser sintering, fused deposition modeling (FDM), and electron beam melting (EBM), especially their advantages and limitations are presented. In particular, selective laser sintering is able to obtain scaffolds with nanoscale grains, due to its high heating rate and a short holding time. However, this character usually results in insufficient densification. FDM can fabricate scaffolds with a relative high accuracy of pore structure but with a relative low mechanical strength. EBM with a high beam-material coupling efficiency can process high melting point metals, but it exhibits a low-resolution and poor surface quality. Furthermore, the common post-treatments, with main focus on heat and surface treatments, which are applied to improve the comprehensive performance are also discussed. Finally, this review also discusses the future directions for AM scaffolds for bone tissue engineering.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.