Evidence map›Paper›PMID 32596228›Full record

SynthesisFrontiers in bioengineering and biotechnology2020

The Treatment of Cartilage Damage Using Human Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Systematic Review of

Kendrick To, Karl Romain, Christopher Mak, Achi Kamaraj, Frances Henson, Wasim Khan

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
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  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. State of the Art: The Immunomodulatory Role of MSCs for Osteoarthritis.International journal of molecular sciences · 2022
    Review
  14. Review
  15. Review
  16. Review
  17. Extracellular Vesicles in Musculoskeletal Pathologies and Regeneration.Frontiers in bioengineering and biotechnology · 2020
    Review
  18. Non-viral Gene Delivery Methods for Bone and Joints.Frontiers in bioengineering and biotechnology · 2020
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kendrick ToDivision of Trauma and Orthopaedics, Department of Surgery, University of Cambridge, Cambridge, United Kingdom.
Karl RomainSchool of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.
Christopher MakDivision of Trauma and Orthopaedics, Department of Surgery, University of Cambridge, Cambridge, United Kingdom.
Achi KamarajSchool of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.
Frances HensonDivision of Trauma and Orthopaedics, Department of Surgery, University of Cambridge, Cambridge, United Kingdom.
Wasim KhanDivision of Trauma and Orthopaedics, Department of Surgery, University of Cambridge, Cambridge, United Kingdom.
University of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Damage to joints through injury or disease can result in cartilage loss, which if left untreated can lead to inflammation and ultimately osteoarthritis. There is currently no cure for osteoarthritis and management focusses on symptom control. End-stage osteoarthritis can be debilitating and ultimately requires joint replacement in order to maintain function. Therefore, there is growing interest in innovative therapies for cartilage repair. In this systematic literature review, we sought to explore the

Indexed as

cartilageextracellular vesiclemesenchymal stem cellosteoarthritistissue engineering

Identifiers

PMID32596228
PMCPMC7300288
OpenAlexW3034382662

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.