Evidence map›Paper›PMID 32596202›Full record

ArticleFrontiers in chemistry2020

Dimeric γ-AApeptides With Potent and Selective Antibacterial Activity.

Minghui Wang, Ruixuan Gao, Peng Sang, Timothy Odom, Mengmeng Zheng, Yan Shi, Hai Xu, Chuanhai Cao, Jianfeng Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Minghui WangDepartment of Chemistry, University of South Florida, Tampa, FL, United States.
Ruixuan GaoDepartment of Chemistry, University of South Florida, Tampa, FL, United States.
Peng SangDepartment of Chemistry, University of South Florida, Tampa, FL, United States.
Timothy OdomDepartment of Chemistry, University of South Florida, Tampa, FL, United States.
Mengmeng ZhengDepartment of Chemistry, University of South Florida, Tampa, FL, United States.
Yan ShiDepartment of Chemistry, University of South Florida, Tampa, FL, United States.
Hai XuCollege of Chemistry and Chemical Engineering, Central South University, Changsha, China.
Chuanhai CaoCollege of Pharmacy, University of South Florida, Tampa, FL, United States.
Jianfeng CaiDepartment of Chemistry, University of South Florida, Tampa, FL, United States.

Funding

Novel polymer biomaterials combating C. difficile infectionR01AI149852 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CAI, JIANFENG, SUN, XINGMIN · 2019 to 2023
$1.9M
Antimicrobial agents derived from AApeptide biomaterialsR01AI152416 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CAI, JIANFENG · 2020 to 2024
$1.9M
NIAID NIH HHS R01 AI149852NIAID NIH HHS R01 AI152416
6 · The paper itself

Abstract

Over the past few decades, the emergence of antibiotic resistance developed by life-threatening bacteria has become increasingly prevalent. Thus, there is an urgent demand to develop novel antibiotics capable of mitigating this trend. Herein, we report a series of dimeric γ-AApeptide derivatives as potential antibiotic agents with limited toxicity and excellent selectivity against Gram-positive strains. Among them, compound

Indexed as

antimicrobialdrug resistanceGram-positive strainshost defense peptideγ-AApeptides

Identifiers

PMID32596202
PMCPMC7304243

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.