ArticlePeerJ2020
KIT is involved in melanocyte proliferation, apoptosis and melanogenesis in the Rex Rabbit.
Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 21 citations in OpenAlex.
- Melanin Deposition and Screening of Melanogenesis-Related Differential RNAs and Construction of ceRNA Regulatory Network in Liancheng White Ducks.Animals : an open access journal from MDPI · 2026Article
- A transcriptome analysis revealing the molecular mechanism of light intensity-driven color variation in the skin of Chinese giant salamander (Andrias davidianus).BMC genomics · 2026Article
- Pangenome-based association testing between a structural variant located upstream of the KIT gene and head depigmentation across a diverse panel of cattle breeds.Genetics, selection, evolution : GSE · 2026Article
- Pigmentation-dependent expression of pheomelanogenesis-related genes in human melanoma cells.Postepy dermatologii i alergologii · 2026Article
- High-salt diet induces immune-independent re-differentiation, metabolic shut down and cell cycle arrest of melanoma.Cell death & disease · 2025Article
- Regulation of melanin synthesis in goat hair follicles by melatonin through the Wnt/β-catenin pathway.Molecular genetics and genomics : MGG · 2025Article
- miRNA-200a suppresses GNAI1 and PLCB4 to modulate skin pigmentation in cashmere goats.Scientific reports · 2025Article
- Article
- Population Genomics Reveals Elevated Inbreeding and Accumulation of Deleterious Mutations in White Raccoon Dogs.Biology · 2025Article
- An analysis of gene expression profiles through machine learning uncovers the new diagnostic signature for diabetic foot ulcers.Frontiers in genetics · 2025Article
- Discovery of Kuraridin as a Potential Natural Anti-Melanogenic Agent: Focusing on Specific Target Genes and Multidirectional Signaling Pathways.International journal of molecular sciences · 2024Article
- Coloration in Equine: Overview of Candidate Genes Associated with Coat Color Phenotypes.Animals : an open access journal from MDPI · 2024Review
- TAD border deletion at the Kit locus causes tissue-specific ectopic activation of a neighboring gene.Nature communications · 2024Article
- Genomic Inbreeding and Runs of Homozygosity Analysis of Cashmere Goat.Animals : an open access journal from MDPI · 2024Article
- Article
- miR-330 targeting BCO2 is involved in carotenoid metabolism to regulate skin pigmentation in rainbow trout (Oncorhynchus mykiss).BMC genomics · 2023Article
- New Butyroside D from Argan Press Cake Possess Anti-Melanogenesis Effect via MITF Downregulation in B16F10 and HEM Cells.International journal of molecular sciences · 2022Article
- CDK1 promotes the proliferation of melanocytes in Rex rabbits.Genes & genomics · 2022Article
- Evaluation of the prevalence of congenital sensorineural deafness in a population of 72 client-owned purebred white cats examined from 2007 to 2021.BMC veterinary research · 2022Article
- Genome-Wide Selective Analysis of Boer Goat to Investigate the Dynamic Heredity Evolution under Different Stages.Animals : an open access journal from MDPI · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMelanocytes play an extremely important role in the process of skin and coat colors in mammals which is regulated by melanin-related genes. Previous studies have demonstrated that KIT is implicated in the process of determining the color of the coat in Rex rabbits. However, the effect of KIT on the proliferation and apoptosis of melanocytes and melanogenesis has not been clarified.
methodsThe mRNA and protein expression levels of KIT were quantified in different coat colored rabbits by qRT-PCR and a Wes assay. To identify whether KIT functions by regulating of melanogenesis, KIT overexpression and knockdown was conducted in melanocytes, and KIT mRNA expression and melanin-related genes TYR, MITF, PMEL and DCT were quantified by qRT-PCR. To further confirm whether KIT influences melanogenesis in melanocytes, melanin content was quantified using NaOH lysis after overexpression and knockdown of KIT. Melanocyte proliferation was estimated using a CCK-8 assay at 0, 24, 48 and 72 h after transfection, and the rate of apoptosis of melanocytes was measured by fluorescence-activated cell sorting.
resultsKITmRNA and protein expression levels were significantly different in the skin of Rex rabbits with different color coats (
conclusionsOur results reveal that KIT is a critical gene in the regulation of melanogenesis, controlling proliferation and apoptosis in melanocytes, providing additional evidence for the mechanism of pigmentation of animal fur.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.