Evidence map›Paper›PMID 32595917›Full record

ReviewEuropean clinical respiratory journal2020

The risk of osteoporosis in patients with asthma.

Indumathi Kumarathas, Torben Harsløf, Charlotte Uggerhøj Andersen, Bente Langdahl, Ole Hilberg, Leif Bjermer, Anders Løkke

Open access · goldAbstract readReview
In one paragraph

Review in European clinical respiratory journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Guideline
  2. Association Between Asthma and Chronic Bone Diseases: A Cross-Sectional Analysis From the Longitudinal Ageing Study in India (LASI) Data.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Observational
  11. Intranasal corticosteroid users in The Netherlands: A drug utilization study.The journal of allergy and clinical immunology. Global · 2024
    Article
  12. Review
  13. Article
  14. Rational use of inhaled corticosteroids for the treatment of COPD.NPJ primary care respiratory medicine · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Indumathi KumarathasDepartment of Clinical Medicine, Steno Diabetes Center Aarhus, Aarhus, Denmark.ORCID 0000-0001-9029-1064
Torben HarsløfDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Charlotte Uggerhøj AndersenDepartment of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark.
Bente LangdahlDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Ole HilbergDepartment of Medicine, Vejle Hospital, Vejle, Denmark.
Leif BjermerDepartment of Respiratory Medicine and Allergology, Skaane University Hospital, Lund, Sweden.
Anders LøkkeDepartment of Medicine, Vejle Hospital, Vejle, Denmark.
Aarhus University Hospital · DKVejle Sygehus · DKAarhus University · DKSkåne University Hospital · SESteno Diabetes Centers · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is well-known that use of continuous systemic corticosteroids (SG) affects bone metabolism, bone mineral density (BMD), and ultimately increases the risk of osteoporosis. In patients with asthma, on the other hand, the effects of long-term high-dose inhaled corticosteroids (ICS) on BMD and risk of osteoporotic fractures is controversial. The reasons for this inconsistency could be explained by the fact that only few long-term studies investigating the effect of ICS in patients with asthma exist. The studies are characterized by different study designs and duration of ICS exposure, small study populations, and differences between the used ICS. The aim of this article is to unravel which factors, if any, that contribute to an increased risk of osteoporosis in patients with asthma and to summarize the evidence regarding adverse effects of ICS on bone metabolism, BMD and osteoporotic fractures in patients with asthma.

Indexed as

adverse effectAsthmabone mineral densityfractureinhaled corticosteroidsoral corticosteroidsosteoporosis

Identifiers

PMID32595917
PMCPMC7301699
OpenAlexW3026436720

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.