Evidence map›Paper›PMID 32595914›Full record

ArticleJournal of extracellular vesicles2020

The αvβ6 integrin in cancer cell-derived small extracellular vesicles enhances angiogenesis.

Shiv Ram Krishn, Israa Salem, Fabio Quaglia, Nicole M Naranjo, Ekta Agarwal, Qin Liu, Srawasti Sarker, Jessica Kopenhaver, Peter A McCue, Paul H Weinreb and 3 more

Abstract read
In one paragraph

Article in Journal of extracellular vesicles, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Article
  2. New insights into extracellular vesicles in metastatic cancer: From mechanisms to diagnostics and targeted therapies.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
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  10. Article
  11. Article
  12. Article
  13. Integrins in cancer stem cells.Frontiers in cell and developmental biology · 2024
    Review
  14. Review
  15. Review
  16. Targeting the αVβ3/NgR2 pathway in neuroendocrine prostate cancer.Matrix biology : journal of the International Society for Matrix Biology · 2023
    Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shiv Ram KrishnProstate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, USA.
Israa SalemProstate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, USA.
Fabio QuagliaProstate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, USA.
Nicole M NaranjoProstate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, USA.
Ekta AgarwalProstate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, USA.
Qin LiuMolecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, USA.ORCID 0000-0001-9964-580X
Srawasti SarkerProstate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, USA.
Jessica KopenhaverDepartment of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, USA.
Peter A McCueDepartment of Pathology, Thomas Jefferson University, Philadelphia, USA.
Paul H WeinrebBiogen Inc., Cambridge, USA.
Shelia M VioletteBiogen Inc., Cambridge, USA.
Dario C AltieriProstate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, USA.
Lucia R LanguinoProstate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, USA.

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
Role of Runx2 in prostate tumorigenesis and metastasisP01CA140043 · NCI · WISTAR INSTITUTE · PI ALTIERI, DARIO C · 2010 to 2021
$12.2M
Integrin-mediated mechanisms of prostate cancer progressionR01CA224769 · NCI · THOMAS JEFFERSON UNIVERSITY · PI LANGUINO, LUCIA R. · 2018 to 2022
$2.0M
NCI NIH HHS P01 CA140043NCI NIH HHS P30 CA010815NCI NIH HHS R01 CA224769
6 · The paper itself

Abstract

Prostate cancer (PrCa) cells crosstalk with the tumour microenvironment by releasing small extracellular vesicles (sEVs). sEVs, as well as large extracellular vesicles (LEVs), isolated via iodixanol density gradients from PrCa cell culture media, express the epithelial-specific αvβ6 integrin, which is known to be induced in cancer. In this study, we show sEV-mediated protein transfer of αvβ6 integrin to microvascular endothelial cells (human microvascular endothelial cells 1 - HMEC1) and demonstrate that

Indexed as

Angiogenesisendothelial cellextracellular vesicleintegrinprostate cancersurvivin

Identifiers

PMID32595914
PMCPMC7301698

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.