Evidence map›Paper›PMID 32595778›Full record

ArticleBeilstein journal of organic chemistry2020

Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow.

Alexander V Nyuchev, Ting Wan, Borja Cendón, Carlo Sambiagio, Job J C Struijs, Michelle Ho, Moisés Gulías, Ying Wang, Timothy Noël

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Beilstein journal of organic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexander V NyuchevMicro Flow Chemistry and Synthetic Methodology, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Het Kranenveld, Bldg 14 - Helix, 5600 MB Eindhoven, The Netherlands.ORCID https://orcid.org/0000-0002-0460-0543
Ting WanMicro Flow Chemistry and Synthetic Methodology, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Het Kranenveld, Bldg 14 - Helix, 5600 MB Eindhoven, The Netherlands.ORCID https://orcid.org/0000-0002-3520-9723
Borja CendónMicro Flow Chemistry and Synthetic Methodology, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Het Kranenveld, Bldg 14 - Helix, 5600 MB Eindhoven, The Netherlands.ORCID https://orcid.org/0000-0003-1783-0839
Carlo SambiagioMicro Flow Chemistry and Synthetic Methodology, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Het Kranenveld, Bldg 14 - Helix, 5600 MB Eindhoven, The Netherlands.ORCID https://orcid.org/0000-0001-8536-103X
Job J C StruijsMicro Flow Chemistry and Synthetic Methodology, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Het Kranenveld, Bldg 14 - Helix, 5600 MB Eindhoven, The Netherlands.ORCID https://orcid.org/0000-0002-6051-2927
Michelle HoMicro Flow Chemistry and Synthetic Methodology, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Het Kranenveld, Bldg 14 - Helix, 5600 MB Eindhoven, The Netherlands.ORCID https://orcid.org/0000-0002-8041-112X
Moisés GulíasCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID https://orcid.org/0000-0001-8093-2454
Ying WangDiscovery Chemistry and Technologies, AbbVie Inc., 1 North Waukegan, Road, North Chicago, Illinois 60064, United States of America.ORCID https://orcid.org/0000-0001-9516-3483
Timothy NoëlMicro Flow Chemistry and Synthetic Methodology, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Het Kranenveld, Bldg 14 - Helix, 5600 MB Eindhoven, The Netherlands.ORCID https://orcid.org/0000-0002-3107-6927

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison to the batch procedure, while achieving similar or higher yields. In addition, the use of inorganic bases was demonstrated to increase the reaction yield under batch conditions.

Indexed as

C–H functionalizationcontinuous-floworganic synthesisphotoredox catalysistrifluoromethoxylation

Identifiers

PMID32595778
PMCPMC7308607

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.