ArticleEvidence-based complementary and alternative medicine : eCAM2020
Antimalarial Activity of Crude Extract and Solvent Fractions of the Leaves of
Article in Evidence-based complementary and alternative medicine : eCAM, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- In vitro antibacterial properties of selected medicinal plants used by traditional healers for gastrointestinal disorders in the Heban-Arsi and Kofale districts of Southern Ethiopia.BMC complementary medicine and therapies · 2026Article
- Antiplasmodial Screening of Phikud Navakot Formulation and In Vivo Evaluation, Toxicity, and Phytochemical Profiling of the PotentScientifica · 2025Article
- Antimalarial and neuroprotective effects of ethanolic extracts of the five-flower remedy in an experimental cerebral malaria model.PloS one · 2025Article
- Optimization of in vivo antimalarial efficacy of combinations of aqueous leaf extracts of Artemisia annua L., Vernonia amygdalina Del, and Microglossa pyrifolia (Lam.) Kuntze using factorial design.BMC complementary medicine and therapies · 2024Article
- Article
- In vivo antimalarial effect of 1-hydroxy-5,6,7-trimethoxyxanthone isolated from Mammea siamensis T. Anders. flowers: pharmacokinetic and acute toxicity studies.BMC complementary medicine and therapies · 2024Article
- In-Vivo Anti-Malarial Activity of 80% Methanol Leaf Extract ofJournal of experimental pharmacology · 2024Article
- The ethnomedicine, phytochemistry, and pharmacological properties of the genus Bersama: current review and future perspectives.Frontiers in pharmacology · 2024Review
- Efficacy of artesunate combined with Atractylodes lancea or Prabchompoothaweep remedy extracts as adjunctive therapy for the treatment of cerebral malaria.BMC complementary medicine and therapies · 2023Article
- Preclinical evaluation of antimalarial activity of CPF-1 formulation as an alternative choice for the treatment of malaria.BMC complementary medicine and therapies · 2023Article
- Senna occidentalis (L.) Link root extract inhibits Plasmodium growth in vitro and in mice.BMC complementary medicine and therapies · 2023Article
- Phytochemical, Antimalarial, and Acute Oral Toxicity Properties of Selected Crude Extracts of Prabchompoothaweep Remedy inTropical medicine and infectious disease · 2022Article
- In vivo assessment of the antimalarial activity and acute oral toxicity of an ethanolic seed extract of Spondias pinnata (L.f.) Kurz.BMC complementary medicine and therapies · 2022Article
- Evaluation of the antidiarrheal activity of 80% methanol extract and solvent fractions of the leaf of Bersama abyssinica fresen (Melianthaceae) in mice.BMC complementary medicine and therapies · 2022Article
- Suppressive, Curative, and Prophylactic Effects ofBioMed research international · 2022Article
- Antiplasmodial Activity of 80% Methanolic Extract and Solvent Fractions of Stem Bark ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Article
- Medicinal plants as a fight against murine blood-stage malaria.Saudi journal of biological sciences · 2021Review
- Antimalarial Activity of Hydromethanolic Crude Extract and Chloroform Fraction ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Antiplasmodial Activity of the Crude Extract and Solvent Fractions of Stem Barks ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTreatment of malaria has been compromised by the emergence of drug-resistant parasites. Consequently, novel agents are urgently needed from different sources including from medicinal plants. Thus, the current study aimed at evaluating the antimalarial activity of crude extract and solvent fractions of the leaves of
methodA 4-day suppressive test was employed to evaluate the antimalarial effect of crude extract and solvent fractions against early infection. The curative and prophylactic effects of crude extract and fraction with the highest chemosuppression were further tested by Rane's test and residual infection procedure. Parasitemia, survival time, packed cell volume (PCV), body weight, and rectal temperature of mice were used as evaluation parameters. Windows SPSS version 20 was used to analyze the data and analysis of variance (ANOVA) followed by Tukey's post hoc test was used to compare data between groups.
resultsThe crude extract and aqueous fraction significantly (
conclusionThe crude extract and fractions showed fairly moderate antimalarial activity, and the finding supports the traditional claims and previous
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.