Evidence map›Paper›PMID 32595640›Full record

ArticleFrontiers in immunology2020

Piperlongumine Acts as an Immunosuppressant by Exerting Prooxidative Effects in Human T Cells Resulting in Diminished T

Jie Liang, Jacqueline D Ziegler, Beate Jahraus, Christian Orlik, Renata Blatnik, Norbert Blank, Beate Niesler, Guido Wabnitz, Thomas Ruppert, Katrin Hübner and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Jie LiangSection Molecular Immunology, Institute of Immunology, Heidelberg University, Heidelberg, Germany.
Jacqueline D ZieglerSection Molecular Immunology, Institute of Immunology, Heidelberg University, Heidelberg, Germany.
Beate JahrausSection Molecular Immunology, Institute of Immunology, Heidelberg University, Heidelberg, Germany.
Christian OrlikSection Molecular Immunology, Institute of Immunology, Heidelberg University, Heidelberg, Germany.
Renata BlatnikMass Spectrometry Core Facility, Center for Molecular Biology (ZMBH), Heidelberg University, Heidelberg, Germany.
Norbert BlankDivision of Rheumatology, Department of Internal Medicine V, Heidelberg University, Heidelberg, Germany.
Beate NieslerDepartment of Human Molecular Genetics, Heidelberg University, Heidelberg, Germany.
Guido WabnitzSection Molecular Immunology, Institute of Immunology, Heidelberg University, Heidelberg, Germany.
Thomas RuppertMass Spectrometry Core Facility, Center for Molecular Biology (ZMBH), Heidelberg University, Heidelberg, Germany.
Katrin HübnerSection Molecular Immunology, Institute of Immunology, Heidelberg University, Heidelberg, Germany.
Emre BaltaSection Molecular Immunology, Institute of Immunology, Heidelberg University, Heidelberg, Germany.
Yvonne SamstagSection Molecular Immunology, Institute of Immunology, Heidelberg University, Heidelberg, Germany.
Heidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Piperlongumine (PL), a natural small molecule derived from the

Indexed as

Cell DifferentiationDioxolanesHumansImmunosuppressive AgentsPiperidonesReactive Oxygen SpeciesTh17 CellsT-Lymphocytes, RegulatoryDioxolanesImmunosuppressive AgentsPiperidonespiperlongumineReactive Oxygen Speciesglutathionepiperlongumineprimary human T cellsreactive oxygen speciesTH17 cellsTreg cells

Identifiers

PMID32595640
PMCPMC7303365
OpenAlexW3035406560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.