Evidence map›Paper›PMID 32595600›Full record

ArticleFrontiers in endocrinology2020

NAMPT and BMAL1 Are Independently Involved in the Palmitate-Mediated Induction of Neuroinflammation in Hypothalamic Neurons.

Andy Tran, Wenyuan He, Nan Jiang, Jim T C Chen, Denise D Belsham

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
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  6. Article
  7. Hypothalamic astrocyte NADNature communications · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Andy TranDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
Wenyuan HeDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
Nan JiangDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
Jim T C ChenDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
Denise D BelshamDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
University of Toronto · CA

Funding

CIHR MOP-133676
6 · The paper itself

Abstract

Obesity is a prominent metabolic disease that predisposes individuals to multiple comorbidities, including type 2 diabetes mellitus, cardiovascular diseases, and cancer. Elevated circulating levels of fatty acids contribute to the development of obesity, in part, by targeting the hypothalamus. Palmitate, the most abundant circulating saturated fatty acid, has been demonstrated to dysregulate NAMPT and circadian clock proteins, as well as induce neuroinflammation. These effects ultimately result in hypothalamic dysregulation of feeding behavior and energy homeostasis. NAMPT is the rate-limiting enzyme of the NAD+ salvage pathway and its expression is under the control of the circadian clock. NAD+ produced from NAMPT can modulate the circadian clock, demonstrating bidirectional interactions between circadian and metabolic pathways. Using NPY/AgRP-expressing mHypoE-46 neurons as well as the novel mHypoA-BMAL1-WT/F and mHypoA-BMAL1-KO/F cell lines, we studied whether there were any interactions between NAMPT and the core circadian clock protein BMAL1 in the palmitate-mediated induction of neuroinflammation. We report that palmitate altered

Indexed as

AnimalsARNTL Transcription FactorsCytokinesFemaleGene Expression RegulationHypothalamusInflammationInflammation MediatorsMaleMiceMice, KnockoutNeuronsNicotinamide PhosphoribosyltransferasePalmitatesARNTL Transcription FactorsBmal1 protein, mouseCytokinesInflammation MediatorsNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, mousePalmitatescircadianhypothalamusinflammationNAMPTobesitypalmitatevisfatin

Identifiers

PMID32595600
PMCPMC7303266
OpenAlexW3035387090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.