Evidence map›Paper›PMID 32595592›Full record

ArticleFrontiers in neurology2020

Is Salivary S100B a Biomarker of Traumatic Brain Injury? A Pilot Study.

Damir Janigro, Keisuke Kawata, Erika Silverman, Nicola Marchi, Ramon Diaz-Arrastia

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07507253 (Pilot Study on the Correlation Between Accelerations Experienced During Matches by Professional Rugby Players and a Profile of Salivary Biomarkers Identified in the Literature as Related to Concussion.), which is not on this map. Cited by 20 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 6 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07507253 recruitingnot on this mapstarted 2025, after this paper: background citation

Pilot Study on the Correlation Between Accelerations Experienced During Matches by Professional Rugby Players and a Profile of Salivary Biomarkers Identified in the Literature as Related to Concussion.

TypeobservationalSponsorSys2DiagRan2025 to 2028Enrolled66ConditionsSport Related ConcussionArmsAnalyze correlations between the measurements of the variations in biomarkers with those obtained by an instrumented mouthguard measuring accelerations.
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 6 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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  19. Frontiers in medical technology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Damir JanigroFloTBI Inc., Cleveland, OH, United States.
Keisuke KawataDepartment of Kinesiology, School of Public Health, Program in Neuroscience, College of Arts and Sciences, Indiana University, Bloomington, IN, United States.
Erika SilvermanDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, United States.
Nicola MarchiCerebrovascular and Glia Research, Department of Neuroscience, Institute of Functional Genomics (CNRS/INSERM), University of Montpellier, Montpellier, France.
Ramon Diaz-ArrastiaDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, United States.
University of Pennsylvania · USCase Western Reserve University · USIndiana University Bloomington · USInstitut de Génomique Fonctionnelle · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) results in short and long-term disability neurodegeneration. Mild traumatic brain injury (mTBI) represents up to 85% of head injuries; diagnosis and early management is based on computed tomography (CT) or in-hospital observation, which are time- and cost- intensive. CT involves exposure to potentially harmful ionizing radiation and >90% of the scans are negative. Blood-brain barrier (BBB) damage is suspected pathological event post-TBI contributing to long-term sequelae and a reliable and rapid point-of-care test to screen those who can safely forego acute head CT would be of great help in evaluating patients with an acute mTBI. In this pilot study, 15 adult patients with suspected TBI (mean age = 47 years, range 18-79) and 15 control subjects (mean age = 33 years, range 23-53) were enrolled. We found that the average salivary S100B level was 3.9 fold higher than blood S100B, regardless of the presence of pathology. [S100B]

Indexed as

blood-brain barriermild traumatic brain injuryperipheral biomarkersS100Bsaliva

Identifiers

PMID32595592
PMCPMC7303321
OpenAlexW3029357014

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.