SynthesisFrontiers in psychiatry2020
Cortisol Responses to Naturally Occurring Psychosocial Stressors Across the Psychosis Spectrum: A Systematic Review and Meta-Analysis.
Synthesis in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Biobehavioral Interactions between Endocannabinoid and Hypothalamicpituitary- adrenal Systems in Psychosis: A Systematic Review.Current neuropharmacology · 2024Pooled it
- Prenatal stress, intimate partner violence and maternal cortisol trajectories: insights from a prospective birth cohort from São Paulo, Brazil.Scientific reports · 2026Article
- Disentangling Environmental and Genetic Influences on Associations Between Childhood Bullying Victimization and Psychotic-Like Experiences.medRxiv : the preprint server for health sciences · 2026Article
- Little evidence that posttraumatic stress is associated with diurnal hormone dysregulation in Turkana pastoralists.Evolution, medicine, and public health · 2025Article
- The day-to-day influence of trauma exposure and sleep dysfunction on everyday stress in youth at familial high-risk for psychotic disorders.Schizophrenia research · 2024Article
- The Translational Future of Stress Neurobiology and Psychosis Vulnerability: A Review of the Evidence.Current neuropharmacology · 2024Review
- Impact of psychosocial stress on facial emotion recognition in schizophrenia and controls: an experimental study in a forensic sample.Frontiers in psychiatry · 2024Article
- The moderating role of hair cortisol in the association of early and recent stress with stress-related phenotypes.Frontiers in psychology · 2023Article
- Hair Cortisol, Perceived Stress, and the Effect of Group Dynamics: A Longitudinal Study of Young Men during Compulsory Military Training in Lithuania.International journal of environmental research and public health · 2022Article
- Cortisol Levels in Childhood Associated With Emergence of Attenuated Psychotic Symptoms in Early Adulthood.Biological psychiatry · 2022Article
- Examining the Relationship Between Hair Cortisol With Stress-Related and Transdiagnostic Subclinical Measures.Frontiers in psychiatry · 2021Article
- Metabolic Dysregulation and Psychosocial Stress in Patients with Schizophrenia Spectrum Disorders: A Case-Control Study.Journal of clinical medicine · 2020Article
- Adverse Childhood Experiences and Methylation of theJournal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundIndividuals with established psychosis and those at high-risk for the disorder have been found to show abnormalities within the hypothalamic-pituitary-adrenal (HPA) axis, including elevations in basal and diurnal cortisol, but a blunted cortisol awakening response. However, the extent to which these features are associated with psychosocial stressors encountered in the natural environment (which are known to be more commonly experienced by these groups, and more distressing) is currently unclear. We therefore conducted a systematic review and meta-analysis to investigate the concordance between naturally-occurring psychosocial stressors and cortisol levels in these populations.
methodsPubMed, PsycINFO, and EMBASE were searched up to November 2019 to identify studies examining the concordance between psychosocial stressors and cortisol in healthy controls and individuals on the psychosis spectrum (patients with established psychosis and/or high-risk individuals). An overall meta-analysis (including data for all stressor-cortisol pairings) was performed to determine the degree of concordance irrespective of group status, with meta-regression employed to test whether the degree of concordance differed in established psychosis and high-risk groups compared to controls. Planned stratified analyses were then performed to examine group differences (where established psychosis and high-risk groups were combined) within individual stressor-cortisol pairings.
resultsEighteen studies (16 datasets) were eligible for inclusion. The overall model, comprising 134 effect sizes, showed that stressors and cortisol measures were only weakly correlated [
conclusionsOverall, we observed poor concordance between naturally-occurring psychosocial stressors and cortisol irrespective of stressor type, cortisol measure, or group status. We consider a range of methodological factors that may have obscured the ability to detect "true" associations and provide recommendations for future studies in this field.
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