ArticleFrontiers in physiology2020
Pathogenesis of Molar Hypomineralisation: Hypomineralised 6-Year Molars Contain Traces of Fetal Serum Albumin.
Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Association between respiratory diseases and molar-incisor hypomineralization: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- A child-centred measure of tooth hypersensitivity for molar incisor hypomineralisation (MIH-TH): development and psychometric evaluation.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- High prevalence of molar-incisor hypomineralisation in sickle cell disease children and the association with haematologic profile: a retrospective cohort study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Posteruptive Loss of Proteins in Porcine Enamel.Journal of dental research · 2025Article
- Socioeconomic factors and feeding in the first two years of life associated with molar incisor hypomineralisation.Frontiers in dental medicine · 2025Article
- Storage conditions differentially alter the human tooth enamel proteome.Frontiers in dental medicine · 2025Article
- Molar incisor hypomineralization: Prevalence, severity and associated aetiological factors in children seeking dental care at Armed Forces Hospital Jazan, Saudi Arabia.The Saudi dental journal · 2024Article
- Proteomic profiling of human dental enamel affected by molar incisor hypomineralisation of different clinical severity grades: an in vitro study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Article
- Proteomic Analyses Discern the Developmental Inclusion of Albumin in Pig Enamel: A New Model for Human Enamel Hypomineralization.International journal of molecular sciences · 2023Article
- Molar-incisor hypomineralisation: an updated view for aetiology 20 years later.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022Article
- A Breakthrough in Understanding the Pathogenesis of Molar Hypomineralisation: The Mineralisation-Poisoning Model.Frontiers in physiology · 2021Article
- Demarcated Opacities as Predictors of Progression of the Molar Incisor Hypomineralisation: a Pilot Study.Acta stomatologica Croatica · 2020Article
- Pathogenesis of Molar Hypomineralisation: Aged Albumin Demarcates Chalky Regions of Hypomineralised Enamel.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molar Hypomineralisation (MH) is gaining cross-sector attention as a global health problem, making deeper enquiry into its prevention a research priority. However, causation and pathogenesis of MH remain unclear despite 100 years of investigation into "chalky" dental enamel. Contradicting aetiological dogma involving disrupted enamel-forming cells (ameloblasts), our earlier biochemical analysis of chalky enamel opacities implicated extracellular serum albumin in enamel hypomineralisation. This study sought evidence that the albumin found in chalky enamel reflected causal events during enamel development rather than later association with pre-existing enamel porosity. Hypothesising that blood-derived albumin infiltrates immature enamel and directly blocks its hardening, we developed a "molecular timestamping" method that quantifies the adult and fetal isoforms of serum albumin ratiometrically. Applying this novel approach to 6-year molars, both isoforms of albumin were detectable in 6 of 8 chalky opacities examined (corresponding to 4 of 5 cases), indicating developmental acquisition during early infancy. Addressing protein survival,
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