ArticleFrontiers in aging neuroscience2020
The Role of Resting-State Network Functional Connectivity in Cognitive Aging.
Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- Trial
- Connecting memory and functional brain networks in older adults: a resting-state fMRI study.GeroScience · 2023Trial
- Combined Cognitive Training and Vortioxetine Mitigates Age-Related Declines in Functional Brain Network Integrity.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023Trial
- Proximal improvement and higher-order resting state network change after multidomain cognitive training intervention in healthy older adults.GeroScience · 2022Trial
- Machine learning and individual variability in electric field characteristics predict tDCS treatment response.Brain stimulationTrial
- An Interpretable Framework for Identifying EEG Spectral Biomarkers of Pathological Brain Aging.Diagnostics (Basel, Switzerland) · 2026Article
- Resting-State and Task Functional Magnetic Resonance Imaging Network Topology Metrics With no Threshold Selection to Predict Cognition.Human brain mapping · 2026Article
- Prenatal Cannabis Exposure Shaping Altered Brain Connectivity: Neural Correlates of Cognitive and Mental Health Variability in Offspring.Research square · 2026Article
- Effects of aerobic exercise intervention on the association between brain functional connectivity and cognition among older adults.Aging brain · 2026Article
- Brain-computer-interface-based intervention increases brain functional segregation in cognitively normal older adults.Age and ageing · 2025Article
- Accelerated Epigenetic Aging and Its Role in Brain Dynamics and Cognition in Young Adulthood.Human brain mapping · 2025Article
- Study on Large-Scale Brain Network Abnormalities in Patients With Beta-Thalassemia.Brain and behavior · 2025Article
- Age and Alzheimer's disease affect functional connectivity along separate axes of functional brain organization.bioRxiv : the preprint server for biology · 2025Article
- Brain Resting-state Functional Connectivity Mediates the Age-associated Decline in Physical Activity Engagement.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- The Journey of the Default Mode Network: Development, Function, and Impact on Mental Health.Biology · 2025Review
- Network segregation is associated with processing speed in the cognitively healthy oldest-old.eLife · 2025Article
- Emotional characteristics and intrinsic brain network functional connectivity among adults aged 75.Social cognitive and affective neuroscience · 2025Article
- Functional connectivity in distributed cortical networks associated with semantic processing in healthy older adults.Frontiers in aging neuroscience · 2025Article
- The brain selectively allocates energy to functional brain networks under cognitive control.Scientific reports · 2024Article
- Whole brain functional connectivity: Insights from next generation neural mass modelling incorporating electrical synapses.PLoS computational biology · 2024Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Aging is associated with disruptions in the resting-state functional architecture of the brain. Previous studies have primarily focused on age-related declines in the default mode network (DMN) and its implications in Alzheimer's disease. However, due to mixed findings, it is unclear if changes in resting-state network functional connectivity are linked to cognitive decline in healthy older adults. In the present study, we evaluated the influence of intra-network coherence for four higher-order cognitive resting-state networks on a sensitive measure of cognitive aging (i.e., NIH Toolbox Fluid Cognition Battery) in 154 healthy older adults with a mean age of 71 and education ranging between 12 years and 21 years (mean = 16). Only coherence within the cingulo-opercular network (CON) was significantly related to Fluid Cognition Composite scores, explaining more variance in scores than age and education. Furthermore, we mapped CON connectivity onto fluid cognitive subdomains that typically decline in advanced age. Greater CON connectivity was associated with better performance on episodic memory, attention, and executive function tasks. Overall, the present study provides evidence to propose CON coherence as a potential novel neural marker for nonpathological cognitive aging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.